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CAS No 480-54-6 , retrorsine Search by region : Norway

  • Name: retrorsine
  • Synonyms: 480-54-6; NSC 107659; HSDB 3530; Usaramine;beta-Longilobine; CCRIS 4338; 12,18-Dihydroxysenecionan-11,16-dione; Retrorsin;retrorsine;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 208-211 °C(lit.)
  • Flash Point: 306.49°C
  • Boiling Point: 583.169°C at 760 mmHg
  • Density: 1.328g/cm3
  • Refractive index: 1.59
  • Safety Statements: 22-36/37/39-45
  • Hazard Symbols: T
  • Flash Point: 306.49°C
  • Molecular Weight: 351.3942
  • InchiKey: BCJMNZRQJAVDLD-CQRYIUNCSA-N
  • InChI: InChI=1S/C18H25NO6/c1-3-12-8-11(2)18(23,
    10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,
    23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1
  • Risk Statements: 25
  • Molecular Formula: C18H25NO6
  • Molecular Structure:CAS No:480-54-6 retrorsine

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480-54-6 RETRORCINE

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References of retrorsine
Title: Retrorsine
CAS Registry Number: 480-54-6
CAS Name: 12,18-Dihydroxysenecionan-11,16-dione
Synonyms: b-longilobine
Molecular Formula: C18H25NO6
Molecular Weight: 351.39
Percent Composition: C 61.52%, H 7.17%, N 3.99%, O 27.32%
Literature References: Hepatotoxic pyrrolizidine alkaloid; common constituent of Senecio species. Isoln from Senecio retrorsus DC, Compositae: R. H. F. Manske, Can. J. Chem. 5, 651 (1931); G. Barger et al., J. Chem. Soc. 1935, 11; from Crotalaria usaramoensis E. G. Baker, Leguminosae: C. C. J. Culvenor, L. W. Smith, Aust. J. Chem. 19, 2127 (1966). Structure: S. M. H. Christie et al., J. Chem. Soc. 1949, 1700; E. C. Leisegang, F. L. Warren, ibid. 1950, 702. Identity with b-longilobine: F. L. Warren et al., J. Am. Chem. Soc. 72, 1421 (1950). Review and evaluation of toxicity and carcinogenicity studies: IARC Monographs 10, 303-312, 333-342 (1976). Comprehensive reviews of pyrrolizidine alkaloids: L. B. Bull et al., The Pyrrolizidine Alkaloids (North Holland, Amsterdam, 1968) 293 pp; F. L. Warren in The Alkaloids vol. 12, R. H. F. Manske, Ed. (Academic Press, New York, 1970) pp 245-331.
Properties: Crystals from ethyl acetate, mp 212° (Barger et al.); 216-216.5° (Bull et al.). [a]D18 -17.6° (c = 1.99 in ethanol). uv max (water): 217 nm (log e 3.85). Readily sol in alcohol, chloroform; slightly sol in water, acetone, ethyl acetate; practically insol in ether.
Melting point: mp 212° (Barger et al.); 216-216.5° (Bull et al.)
Optical Rotation: [a]D18 -17.6° (c = 1.99 in ethanol)
Absorption maximum: uv max (water): 217 nm (log e 3.85)
 
Derivative Type: N-Oxide
Synonyms: Isatidine; 12,18-dihydroxysenecionan-11,16-dione-4-oxide; retrorsine N-oxide
Molecular Formula: C18H25NO7
Molecular Weight: 367.39
Percent Composition: C 58.85%, H 6.86%, N 3.81%, O 30.48%
Literature References: Isolated from Senecio species. Review and evaluation of carcinogenicity and toxicity studies: IARC Monographs 10, 269-273 (1976).
Properties: Crystals from ethanol, mp 140.5-141.5° (Christie et al.).
Melting point: mp 140.5-141.5° (Christie et al.)