CAS No 485-71-2 , Cinchonidine Search by region : India

Name: Cinchonidine
Synonyms: alpha-Quinidine; 98%; L-Cinchonidine; alpha-Quinidine; (8alpha,9R)-Cinchonan-9-ol;4-Quinolyl-(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol;Cinchonidine;
CAS Registry Number:485-71-2
Transport: 1544
Melting Point: 204-206 ºC
Density: 1.2 g/cm³
Refractive index: -107.5 ° (C=1, EtOH)
Alpha: -115 º (C=1, ETOH)
Safety Statements: R20/21/22
Hazard Symbols: Xn: Harmful;
HS Code: 29392900
EINECS: 207-622-3
Molecular Weight: 294.39
InChI: InChI=1/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2
Risk Statements: S36/37
Molecular Formula: C19H22N2O
Molecular Structure:

Related products

Select to

          
           485-71-2 CINCHONIDINE 
           
             JAI RADHE SALES
             
              null
Fax: 0091-79-26569884
Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT  , INDIA. null,nullIndia

           485-71-2 CINCHONIDINE
           CINCHONIDINE
 
             CHEMPURE 
             
              [Manufacturer]
Tel: 0091-22-26764461/ 0091-22-26764462  
Fax: 0091-22-26764023 
Address: 328,Ashirwad Industrial Estate Bldg No.3 
Ram Mandir Road,Goregaon (West)
Mumbai- 400104
India
Tel:0091-22-26764461
      0091-22-26764462 
      0091-22-26764139 
Fax:0091-22-26764023
Cell: 09821531478
email: chempure@bom2.vsnl.net.in
400104  MUMBAI MUMBAI,nullIndia

           485-71-2 Cinchonidine
           
             Shreeji Pharma International
             
              [Manufacturers]
Tel: +91-265-3019110
Fax: +91-265-2465036
Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia

           485-71-2 Cinchonidine
           
             Biokemix
             
              [Importer/Exporter]
Tel: +91-(40)-6613 6366
Fax: +91-(40)-6683 6366
Address: Kanchan, 10, Umanagar, Begumpet, Hyderabad, Andhra Pradesh 500016,  Manchester,nullIndia

           485-71-2 CINCHONIDINE
           
             Alchem International Limited
             
              [Manufacturer]
Tel:  +91 129 4266000
Fax:  +91 129 2307192
Address: Alchem International Limited
301, Avalon Apartments
M.G. Road, Sultanpur
New Delhi-110 030 null,nullIndia

Select to

1/1

References of Cinchonidine

Title: Cinchonidine
CAS Registry Number: 485-71-2
CAS Name: (8a,9R)-Cinchonan-9-ol
Synonyms: cinchovatine; a-quinidine
Molecular Formula: C19H22N2O
Molecular Weight: 294.39
Percent Composition: C 77.52%, H 7.53%, N 9.52%, O 5.43%
Literature References: Occurs in most varieties of cinchona bark, especially in bark of Cinchona pubescens Vahl. (C. succirubra Pav.) and C. pitayensis Wedd., Rubiaceae. Isoln: Leers, Ann. 82, 147 (1852). Structure: Rabe, ibid. 365, 359 (1909). Stereoisomeric with cinchonine: Koenigs, ibid. 347, 182 (1906). Configuration: Prelog, Zalán, Helv. Chim. Acta 27, 535 (1944); Prelog, H?fliger, ibid. 33, 2021 (1950); Roth, Pharmazie 16, 257 (1961); Lyle, Keefer, Tetrahedron 23, 3253 (1967). Biosynthetic studies: Battersby, Parry, Chem. Commun. 1971, 31. Toxicity studies: C. C. Johnson, C. F. Poe, Acta Pharmacol. Toxicol. 4, 265 (1948); E. W. Schafer, Jr. et al., Ecotoxicol. Environ. Saf. 6, 149 (1982).
Properties: Orthorhombic plates, prisms from alcohol, mp 210°. [a]D20 -109.2° (alc). uv absorption data: Kamath et al., Indian J. Chem. 6, 510 (1968). Sol in alcohol and chloroform; moderately sol in ether. Practically insol in water. pK1 5.80, pK2 10.03. Protect from light. LD50 i.p. in rats: 206 mg/kg (Johnson, Poe). LD50 orally in quail: >316 mg/kg (Schafer).
Melting point: mp 210°
pKa: pK1 5.80, pK2 10.03
Optical Rotation: [a]D20 -109.2° (alc)
Toxicity data: LD50 i.p. in rats: 206 mg/kg (Johnson, Poe); LD50 orally in quail: >316 mg/kg (Schafer)

Derivative Type: Dihydrochloride
Molecular Formula: C19H22N2O.2HCl
Molecular Weight: 367.31
Percent Composition: C 62.13%, H 6.59%, N 7.63%, O 4.36%, Cl 19.30%
Properties: White or slightly yellow crystals or powder. Freely sol in water or alcohol. Protect from light.

Derivative Type: Hydrochloride dihydrate
Molecular Formula: C19H22N2O.HCl.2H2O
Molecular Weight: 366.88
Percent Composition: C 62.20%, H 7.42%, N 7.64%, O 13.08%, Cl 9.66%
Properties: Cryst powder; loses all of its H2O at 120°. [a]D20 -117.5° (water). Sol in 25 parts cold water, more sol in boiling water; sol in alcohol, chloroform, slightly in ether. The aq soln is practically neutral. Protect from light.
Optical Rotation: [a]D20 -117.5° (water)

Derivative Type: Sulfate trihydrate
Molecular Formula: (C19H22N2O)2.H2SO4.3H2O
Molecular Weight: 740.91
Percent Composition: C 61.60%, H 7.07%, N 7.56%, O 19.43%, S 4.33%
Properties: Silky, acicular crystals; efflorescent on exposure to air and darkens in light. mp when anhydr ~240° with decompn. One gram dissolves in 70 ml water, 20 ml hot water, 90 ml alcohol, 40 ml hot alc, 620 ml chloroform. Practically insol in ether. The aq soln is practically neutral. Protect from light.
Melting point: mp when anhydr ~240° with decompn

Derivative Type: Epicinchonidine
CAS Registry Number: 550-54-9
CAS Name: (8a,9S)-Cinchonan-9-ol
Properties: mp 104°, [a]D20 +63° (c = 0.804 in alc): Rabe et al., Ann. 492, 253 (1932).
Melting point: mp 104°
Optical Rotation: [a]D20 +63° (c = 0.804 in alc): Rabe et al., Ann. 492, 253 (1932)

Therap-Cat: Antimalarial.
Keywords: Antimalarial.