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CAS No 487-79-6 , 3-Pyrrolidineaceticacid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-

  • Name: 3-Pyrrolidineaceticacid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-
  • Synonyms: Digenic acid;(2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic acid; L-a-Kainic acid; (-)-Kainic acid; Kainic acid; (-)-a-Kainic acid; Helminal;3-Pyrrolidineaceticacid, 2-carboxy-4-(1-methylethenyl)-, [2S-(2a,3b,4b)]-;3-Pyrrolidineaceticacid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-;Digenin; a-Kainic acid; 3-Pyrrolidineacetic acid,2-carboxy-4-isopropenyl- (6CI,7CI,8CI);
  • CAS Registry Number:
  • Density: 1.22 g/cm3
  • Refractive index: 1.508
  • Water Solubility: soluble in water
  • Safety Statements: A poison by intraperitoneal, intravenous, and intracerebral routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
  • Hazard Symbols: Xn
  • Molecular Weight: 213.26
  • InChI: InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
  • Risk Statements: 20/21/22
  • Molecular Formula: C10H15 N O4
  • Molecular Structure:CAS No:487-79-6 3-Pyrrolidineaceticacid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-

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487-79-6 Kainic Acid

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References of 3-Pyrrolidineaceticacid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-
Title: Kainic Acid
CAS Registry Number: 487-79-6
CAS Name: [2S-(2a,3b,4b)]-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
Synonyms: 2-carboxy-3-carboxymethyl-4-isopropenylpyrrolidine; digenic acid; a-kainic acid; LS-xylo-kainic acid
Trademarks: Digenin; Helminal
Molecular Formula: C10H15NO4
Molecular Weight: 213.23
Percent Composition: C 56.33%, H 7.09%, N 6.57%, O 30.01%
Literature References: Anthelmintic principle from the dried red alga Digenea simplex (Wulf.) Ag., Rhodomelaceae: Murakami et al., J. Pharm. Soc. Jpn. 73, 1026 (1953); JP 54 4947 (1954), C.A. 49, 13604i (1955); Katsuya et al., JP 64 1942 (1964 to New-Japan Pharmaceutical Co). Structure: Watase, Nitta, Bull. Chem. Soc. Jpn. 30, 889 (1957); Watase et al., ibid. 31, 714 (1958). Eight theoretical stereoisomers, Nitta et al., Nature 181, 761 (1958); GB 795750 (1958 to Takeda). Synthesis: Ueno, US 2902492; Tatsuoka et al., US 2954384 (1959, 1960 both to Takeda); W. Oppolzer, H. Andres, Helv. Chim. Acta 62, 2282 (1979). Excitotoxic amino acid used to identify a specific subset of EAA receptors. Consequently the receptors are known as kainate receptors. Neurotoxic activity: J. V. Nadler, Life Sci. 24, 289 (1979). Mechanism of neurotoxicity: E. G. McGeer et al., Adv. Neurol. 23, 577 (1979); J. T. Coyle et al., ibid. 593; J. W. Ferkany et al., Nature 298, 757 (1982); J. Garthwaite, G. Garthwaite, ibid. 305, 138 (1983). Induces epileptogenic lesions: J. V. Nadler, Neurosci. Res. Program Bull. 19, 369 (1981). Autoradiographic characterization of binding sites: J. T. Greenamyre et al., J. Pharmacol. Exp. Ther. 233, 254 (1985). Book: Kainic Acid as a Tool in Neurobiology, E. G. McGeer et al., Eds. (Raven Press, New York, 1978). Review: J. T. Coyle, Ciba Found. Symp. 126, 186-203 (1987).
Properties: Needles, dec 251°. [a]D24 -14.8° (c = 1.01). Intense absorption at 6.05 and 11.2 m. Sol in water. Insol in ethanol. Stable in boiling aq solns.
Optical Rotation: [a]D24 -14.8° (c = 1.01)
Use: Neurobiological tool.
Therap-Cat: Anthelmintic (Nematodes).
Keywords: Anthelmintic (Nematodes).