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CAS No 49562-28-9 , propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

  • Name: propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
  • Synonyms: Tricor; Lipantil; Fenobrate; Lipidil;propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate;Lipanthyl; Secalip; Procetofen; Antara; Triglide;
  • CAS Registry Number:
  • Melting Point: 80-810C
  • Density: 1.177 g/cm3
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 256-376-3
  • Molecular Weight: 360.83134
  • InchiKey: YMTINGFKWWXKFG-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,
    4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
  • Risk Statements: S36
  • Molecular Formula: C20H21ClO4
  • Molecular Structure:CAS No:49562-28-9 propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

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References of propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
Title: Fenofibrate
CAS Registry Number: 49562-28-9
CAS Name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid 1-methylethyl ester
Synonyms: isopropyl [4￠-(p-chlorobenzoyl)-2-phenoxy-2-methyl]propionate; procetofen; procetofene
Manufacturers' Codes: LF-178
Trademarks: Ankebin (Volpino); Elasterin (Phoenix); Fenobrate (Gramon); Fenotard (Virbac); Lipanthyl (Fournier); Lipantil (Fournier); Lipidil (Ibirn); Lipoclar (Crinos); Lipofene (Teofarma); Liposit (SIT); Lipsin (Fournier); Nolipax (Foscama); Procetoken (Bernabo); Protolipan (Millet); Secalip (Fournier); Tricor (Abbott)
Molecular Formula: C20H21ClO4
Molecular Weight: 360.83
Percent Composition: C 66.57%, H 5.87%, Cl 9.83%, O 17.74%
Literature References: Prepn: A. Mieville, DE 2250327 (1973 to Orchimed), C.A. 79, 53029 (1973), addn to DE 2003430; eidem, US 4058552 (1970, 1977 both to Orchimed). Series of articles on synthesis, metabolism, pharmacology and clinical trials: Arzneim.-Forsch. 26, 885-909 (1976). Toxicity data: R. Sornay et al., ibid. 885. GC-MS of major metabolite in humans: L. F. Elsom et al., J. Chromatogr. 123, 463 (1976). Efficacy in hyperlipidemias: H. B. St?helin et al., Praxis 68, 24 (1979). Effect on human biliary lipids: E. M. Grandjean et al., Schweiz. Med. Wochenschr. 109, 601 (1979). Mechanism of action: W. Wülfert et al., Artery 9, 120 (1981).
Properties: Crystals from isopropanol, mp 80-81°. Practically insol in water. Slightly sol in methanol, ethanol. Sol in acetone, ether, benzene, chloroform. LD50 in mice: 1600 mg/kg orally (Sornay).
Melting point: mp 80-81°
Toxicity data: LD50 in mice: 1600 mg/kg orally (Sornay)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.