Title: Guvacine
CAS Registry Number: 498-96-4
CAS Name: 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid
Synonyms: 1,2,5,6-tetrahydronicotinic acid
Molecular Formula: C6H9NO2
Molecular Weight: 127.14
Percent Composition: C 56.68%, H 7.14%, N 11.02%, O 25.17%
Literature References: From betel nuts, the seeds of
Areca catechu L.,
Palmae. Extraction: Jahns,
Ber. 24, 2615 (1891). Synthesis: Freudenberg,
ibid. 51, 976, 1669 (1918); Hess, Leibbrandt,
ibid. 51, 806;
52, 206 (1919).
Properties: Prisms from water, dec 295°. Neutral to litmus. Sol in water. Almost insol in abs alc, ether, chloroform, benzene.
Derivative Type: Hydrochloride
Molecular Formula: C6H10ClNO2
Molecular Weight: 163.60
Percent Composition: C 44.05%, H 6.16%, Cl 21.67%, N 8.56%, O 19.56%
Properties: Needles from water, dec 318°. Sol in water.
Derivative Type: Hydrobromide
Molecular Formula: C6H10BrNO2
Molecular Weight: 208.05
Percent Composition: C 34.64%, H 4.84%, Br 38.41%, N 6.73%, O 15.38%
Properties: Needles from abs alcohol, dec 280°. Almost insol in acetone.
Use: Has been proposed as growth factor for
Staphylococcus aureus and
Proteus vulgaris instead of nicotinic acid.
