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CAS No 50-35-1 , 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

  • Name: 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • Synonyms: Theophilcholine; Psychotablets; Talimol; Corronarobetin; Distaval;Thalomid; Algosediv; Sedoval; Softenon;2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 269-271 ºC
  • Density: 1.503 g/cm3
  • Refractive index: 1.646
  • Water Solubility: <0.1 G/100 ML AT 22 ºC
  • Safety Statements: R46;R61;R21;R25;R62
  • Hazard Symbols: T: Toxic;
  • EINECS: 200-031-1
  • Molecular Weight: 258.2295
  • InchiKey: UEJJHQNACJXSKW-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13
    (15)19/h1-4,9H,5-6H2,(H,14,16,17)
  • Risk Statements: S53;S22;S26;S36/37/39;S45
  • Molecular Formula: C13H10N2O4
  • Molecular Structure:CAS No:50-35-1 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
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50-35-1 SC-201445 THALIDOMIDE

  • United States Santa Cruz Biotechnology, Inc. [Manufacturer]
  • Tel: 831-457-3800/ 800-457-3801
  • Fax: 831-457-3801
  • Address: Santa Cruz Biotechnology, Inc.
    2145 Delaware Ave.
    Santa Cruz, CA 95060 null,nullUnited States
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50-35-1 THALIDOMIDE-D4

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
  • Fax: +91-22-6693 5687
  • Address: 110 & 111, Kartik Complex
    New link Road, Andheri-(W)
    Mumbai-400053, INDIA. null,nullIndia
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50-35-1 Thalidomide

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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50-35-1 THALIDOMIDE-D4

  • United States EJY Tech, Inc. [Manufacturer]
  • Tel: 301-526-7059
  • Fax: 301-561-6521
  • Address: 9430 Key West Avenue
    Suite 220
    Rockville , MD 20850 null,nullUnited States
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50-35-1 Thalidomide

  • United States Tecoland Corporation null
  • Tel: +1-(732)-603-9577
  • Fax: +1-(732)-906-1522
  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, null,nullUnited States
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50-35-1 Thalidomide

  • China Taizhou Crene Chempharm Co., Ltd. null
  • Tel: +86-(576)-88813233
  • Fax: +86-(576)-88670057
  • Address: Weiwu Load Economic Developed Zone, Taizhou, Zhejiang 318000, null,nullChina
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50-35-1 Thalidomide

  • China Luna Chemicals Co.,Ltd. null
  • Fax: +86-571-85775960
  • Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China null,nullChina
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50-35-1 thalidomide

  • Japan Nacalai Tesque, Inc. [Manufacturers]
  • Tel: 81 75 251 1723 81-75-251-1730
  • Fax: 81-75-251-1763
  • Address: Nijo Karasuma, Nakagyo-ku Kyoto 604-0855 Japan Nakagyo-ku,KyotoJapan
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50-35-1 thalidomide

  • China Shanghai Hao Su Chem-Tech lnc. [Manufacturers]
  • Tel: 021-6661 0036 021-5653 8833
  • Fax: (86 21) 5653 3269
  • Address: 201-204,2 BLDG,1009 North Zhong Shan Road, Shanghai Shanghai,ShanghaiChina
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50-35-1 THALIDOMIDE

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
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References of 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Title: Thalidomide
CAS Registry Number: 50-35-1
CAS Name: 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Synonyms: N-(2,6-dioxo-3-piperidyl)phthalimide; a-phthalimidoglutarimide; 3-phthalimidoglutarimide; 2,6-dioxo-3-phthalimidopiperidine; N-phthalylglutamic acid imide; N-phthaloylglutamimide
Manufacturers' Codes: K-17
Trademarks: Contergan; Neurosedyn; Softenon; Thalomid (Celgene)
Molecular Formula: C13H10N2O4
Molecular Weight: 258.23
Percent Composition: C 60.47%, H 3.90%, N 10.85%, O 24.78%
Literature References: Selective inhibitor of tumor necrosis factor a (TNF-a). Formerly used as sedative, hypnotic. Prepn: GB 768821 (1957 to Chemie Grünenthal). Teratogenicity studies: I. D. Fratta et al., Toxicol. Appl. Pharmacol. 7, 268 (1965). Review of proposed mechanisms of embryopathy: T. D. Stephens, Teratology 38, 229-239 (1988). HPLC determn in plasma: A. Delon et al., J. Liq. Chromatogr. 18, 297 (1995). Stereospecific determn and pharmacokinetics of enantiomers: T. Eriksson et al., Chirality 7, 44 (1995). Clinical trial in HIV wasting syndrome: G. Reyes-Terán et al., AIDS 10, 1501 (1996); in aphthous ulcers related to HIV infection: J. M. Jacobson et al., N. Engl. J. Med. 336, 1487 (1997). Review of chemistry, pharmacokinetics and clinical safety: V. Günzler, Drug Saf. 7, 116-134 (1992); of effect on TNF-a and clinical use in leprosy and tuberculosis: J. D. Klausner et al., Clin. Immunol. Immunopathol. 81, 219-223 (1996); of pharmacology, history and potential clinical uses: D. Stirling et al., J. Am. Pharm. Assoc. NS37, 307-313 (1997); of use in multiple myeloma: S. V. Rajkumar, Expert Rev. Anticancer Ther.1, 20-28 (2001); of pharmacology and toxicology: C. Meierhofer, C. J. Wiedermann, Curr. Opin. Drug Disc. Devel. 6, 92-99 (2003); of clinical experience: S. J. Matthews, C. McCoy, Clin. Ther. 25, 342-395 (2003).
Properties: Needles, mp 269-271°. uv max (neutral soln): 220, 300 nm. Soly in water: ~2 ′ 10-4 mol/L; 45-60 mg/L. Sparingly sol in water, methanol, ethanol, acetone, ethyl acetate, butyl acetate, glacial acetic acid. Very sol in dioxane, DMF, pyridine. Practically insol in ether, chloroform, benzene.
Melting point: mp 269-271°
Absorption maximum: uv max (neutral soln): 220, 300 nm
Therap-Cat: Immunomodulator.
Keywords: Sedative/Hypnotic; Piperidinediones; Immunomodulator.