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CAS No 50-49-7 , 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine Search by region : Canada

  • Name: 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
  • Synonyms: 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine; Dimipressin; Melipramine; Dynaprin; Nelipramin;Imidobenzyle; Intalpram; Berkomine; Melipramin; Antideprin;
  • CAS Registry Number:
  • Flash Point: 179.7°C
  • Boiling Point: 403.1°Cat760mmHg
  • Density: 1.041g/cm3
  • Refractive index: 1.574
  • Safety Statements: A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: somnolence, hallucinations, distorted perceptions, changes in motor activity, ataxia (loss of muscle coordination), coma, nausea and vomiting, irritative dermatitis. An experimental teratogen by ingestion. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 179.7°C
  • EINECS: 200-042-1
  • Molecular Weight: 280.40726
  • InchiKey: BCGWQEUPMDMJNV-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-
    11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
  • Molecular Formula: C19H24N2
  • Molecular Structure:CAS No:50-49-7 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine

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References of 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Title: Imipramine
CAS Registry Number: 50-49-7
CAS Name: 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine
Synonyms: 5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine; N-(g-dimethylaminopropyl)iminodibenzyl; imizin
Manufacturers' Codes: G-22355
Molecular Formula: C19H24N2
Molecular Weight: 280.41
Percent Composition: C 81.38%, H 8.63%, N 9.99%
Literature References: Tricyclic antidepressant. Prepn: Haefliger, Schindler, US 2554736 (1951 to Geigy); eidem, Helv. Chim. Acta 37, 472 (1954). Reviews of pharmacology: Crismon, Psychopharmacol. Bull. 4, 151 pp (Oct. 1967); Glassman, Perel, Arch. Gen. Psychiatry 28, 649 (1973). Toxicity data: A. Tobe et al., Arzneim.-Forsch. 31, 1278 (1981). Comprehensive description: D. N. Kender, R. E. Schiesswohl, Anal. Profiles Drug Subs. 14, 37-75 (1985). Comparative clinical trials in depression: R. S. Lipman et al., Arch. Gen. Psychiatry 43, 68 (1986); in anxiety: R.J. Kahn et al., ibid. 79. Clinical trial for panic disorder: D. H. Barlow et al., J. Am. Med. Assoc. 283, 2529 (2000).
Properties: Free base, bp0.1 160°.
Boiling point: bp0.1 160°
 
Derivative Type: Hydrochloride
CAS Registry Number: 113-52-0
Trademarks: Chrytemin (Fujinaga); Deprinol (Dumex); Feinalmin (Sanko); Imidol (Yoshitomi); Imilanyle (Takata); Imiprin (CP Protea); Janimine (Abbott); Melipramine (EGYT); Presamine (USV); Pryleugan (Temmler); Tofranil (Novartis)
Molecular Formula: C19H24N2.HCl
Molecular Weight: 316.87
Percent Composition: C 72.02%, H 7.95%, N 8.84%, Cl 11.19%
Properties: Crystals from acetone, mp 174-175°. Acquires a yellow to reddish discoloration under the influence of light. Freely sol in water, less sol in alcohol, sparingly sol in acetone. LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe).
Melting point: mp 174-175°
Toxicity data: LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)
 
Derivative Type: Pamoate
CAS Registry Number: 10075-24-8
Trademarks: Tofranil-PM (Novartis)
Molecular Formula: (C19H24N2)2.C23H16O6
Molecular Weight: 949.18
Percent Composition: C 77.19%, H 6.80%, N 5.90%, O 10.11%
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.