Home > Name List By 3 > 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine

CAS No 50-53-3 , 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine

  • Name: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
  • Synonyms: Aminazine;3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine; Contomin; Propaphenin; Chlorderazin; Chloropromazine; Fenactil; Megaphen; Thorazine;Largactil;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 192 - 196 C (decomposes)
  • Flash Point: 226°C
  • Boiling Point: 450.1°Cat760mmHg
  • Density: 1.212g/cm3
  • Water Solubility: Soluble
  • Hazard Symbols: 6.1 (Packing Group: III) UN NO.
  • Flash Point: 226°C
  • EINECS: 200-045-8
  • Molecular Weight: 318.86416
  • InchiKey: ZPEIMTDSQAKGNT-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13
    (18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
  • Molecular Formula: C17H19ClN2S
  • Molecular Structure:CAS No:50-53-3 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Search by region :

Select to

50-53-3 CHLORPROMAZINE

  • United States ACIC [Manufacturer]
  • Tel: 800-265-6727/ 519-751-3668
  • Fax: 519-751-1378
  • Address: 11772 West Sample Road,
    Coral Springs, Florida, 33065 USA null,nullUnited States
Contact Supplier

50-53-3 chlorpromazine

Contact Supplier

50-53-3 Chlorpromazine

Contact Supplier

Select to

References of 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Title: Chlorpromazine
CAS Registry Number: 50-53-3
CAS Name: 2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine
Synonyms: 2-chloro-10-(3-dimethylaminopropyl)phenothiazine; 3-chloro-10-(3-dimethylaminopropyl)phenothiazine; N-(3-dimethylaminopropyl)-3-chlorophenothiazine
Manufacturers' Codes: 2601-A; HL-5746; RP-4560; SKF-2601-A
Molecular Formula: C17H19ClN2S
Molecular Weight: 318.86
Percent Composition: C 64.03%, H 6.01%, Cl 11.12%, N 8.79%, S 10.06%
Literature References: Prepn: Charpentier et al., Compt. Rend. 235, 59 (1952); Charpentier, US 2645640 (1953 to Rh?ne-Poulenc). Effects of neuroleptics on dopamine receptors: N.-E. Anden et al., Eur. J. Pharmacol. 11, 303 (1970). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Review of analytical methods for determn in pharmaceutical prepns: L. F. S. Chagonda, J. S. Millership, J. Pharm. Biomed. Anal. 7, 271-278 (1989). Brief historical review: G. Curzon, Trends Pharmacol. Sci. 11, 61-63 (1990).
Properties: Oily liq. Amine odor. Alkaline reaction. bp0.8 200-205°.
Boiling point: bp0.8 200-205°
 
Derivative Type: Hydrochloride
CAS Registry Number: 69-09-0
Trademarks: Ampliactil (Aventis); Amplictil (Aventis); Chloractil (DDSA); Chlorazin (Streuli); Contomin (Takeda); Fenactil (Jelfa); Hibernal (Aventis); Largactil (Aventis); Plegomazin (Servier); Promacid (CID); Promactil (Combiphar); Propaphenin (Rodleben); Prozin (Lusofarmaco); Taroctyl (Taro); Thorazine (GSK); Wintermin (Shionogi)
Molecular Formula: C17H19ClN2S.HCl
Molecular Weight: 355.33
Percent Composition: C 57.46%, H 5.67%, Cl 19.95%, N 7.88%, S 9.02%
Properties: Crystals, dec 179-180° (capillary); 194-196° (microblock). uv curve: Neuhoff, Auterhoff, Arch. Pharm. 288, 400 (1955). pH of 5% aq soln 4.0-5.5. One gram dissolves in 2.5 ml water. Sol in methanol, ethanol, chloroform. Practically insol in ether, benzene. Slightly acid to litmus. LD50 orally in rats: 225 mg/kg (Goldenthal).
Toxicity data: LD50 orally in rats: 225 mg/kg (Goldenthal)
 
Therap-Cat: Antiemetic; antipsychotic.
Therap-Cat-Vet: Antiemetic; tranquilizer.
Keywords: Antiemetic; Antipsychotic; Phenothiazines.