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CAS No 50-78-2 , 2-acetyloxybenzoic acid

  • Name: 2-acetyloxybenzoic acid
  • Synonyms: Acetosal; Acylpyrin;2-acetyloxybenzoic acid; Polopiryna; Ecotrin; Acenterine; Colfarit; 2-Acetoxybenzoic acid;ACETYLSALICYLIC ACID;
  • CAS Registry Number:
  • Transport: UN 1851
  • Melting Point: 136-140 ºC
  • Flash Point: 250 ºC
  • Boiling Point: 140 C
  • Density: 1.35
  • Water Solubility: 3.3 G/L (20 ºC)
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 250 ºC
  • EINECS: 200-064-1
  • Molecular Weight: 180.15742
  • InchiKey: BSYNRYMUTXBXSQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
  • Risk Statements: S26;S36/37/39
  • Molecular Formula: C9H8O4
  • Molecular Structure:CAS No:50-78-2 2-acetyloxybenzoic acid
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50-78-2 ASPIRIN

  • United States Cayman Chemical Company [Manufacturer]
  • Tel: 734-975-3939; 734-975-3897 (Sales)/ 800-364-9897 (Customer Service)
  • Address: 1180 E.Ellsworth Rd.
    Ann Arbor, MI 48197
    800-364-9897 null,nullUnited States
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50-78-2 Acetylsalicylic Acid

  • China Laiwu Hehui Chemical Co.,Ltd. null
  • Tel: +86-(531)-88772589
  • Fax: +86-(531)-88772589
  • Address: Huashan Rd., Jinan City, Shandong 250000, null,nullChina
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50-78-2 Acetylsalicylic Acid

  • India Manus Aktteva null
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, null,nullIndia
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50-78-2 Acetylsalicylic acid

  • Acetylsalicylic acid
  • United States Research Organics, Inc. [Manufacturer]
  • Tel: 216-883-8025/ 800-321-0570
  • Fax: 216-883-1576
  • Address: 4353 East 49th Street
    Cleveland, OH 44125 null,nullUnited States
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50-78-2 ASPIRIN

  • China Hainan Zhongxin Chemical Co., Ltd. [Manufacturer]
  • Tel: + 86 898 6854 0310/ + 86 21 64361616
  • Fax: + 86 898 6854 0119
  • Address: HAINAN COMPANY
    Address: Rm 811, Hainan Mandarin Hotel,
    Binhai Avenue, Haikou city,
    Hainan, P.R.China
    Tel: + 86 898 6854 0310
    Fax: + 86 898 6854 0119 null,nullChina
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50-78-2 Acetylsalicylic acid

  • Hong kong ADVANCED TECH. & IND. CO., LTD. [Distributor/Wholesaler]
  • Tel: 86-23902293
  • Fax: 86-27898314
  • Address: UNIT B, 1/F, CHEONG SHING IND. BLDG., 17 WALNUT ST., TAI KOK TSUI, KLN, HONG KONG Hong Kong,nilHong kong
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50-78-2 Aspirin

  • China Betapharma(Shanghai)Co., Ltd. null
  • Tel: +86-(21)-33538380
  • Fax: +86-(21)-32082820
  • Address: No.17#-6D. 830 Lane, Maotai Road, Shanghai 200336, null,nullChina
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50-78-2 Acetylsalicylic Acid

  • United States Alfa Chem null
  • Tel: +1-(516)-504-0059, 800-375-6869
  • Fax: +1-(516)-504-0039
  • Address: 2 Harbor Way, Kings Point, New York 11024, null,nullUnited States
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50-78-2 ACETYLSALICYLIC ACID

  • ACETYLSALICYLIC ACID
  • India CHEMPURE [Manufacturer]
  • Tel: 0091-22-26764461/ 0091-22-26764462
  • Fax: 0091-22-26764023
  • Address: 328,Ashirwad Industrial Estate Bldg No.3 Ram Mandir Road,Goregaon (West) Mumbai- 400104 India Tel:0091-22-26764461 0091-22-26764462 0091-22-26764139 Fax:0091-22-26764023 Cell: 09821531478 email: chempure@bom2.vsnl.net.in 400104 MUMBAI MUMBAI,nullIndia
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50-78-2 Acetylsalicylic Acid

  • United States Parchem Trading [Manufacturer]
  • Tel: 914.654.6800
  • Fax: 914.654.6899
  • Address: Parchem Trading Ltd.
    415 Huguenot Street
    New Rochelle, NY 10801 null,nullUnited States
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References of 2-acetyloxybenzoic acid
Title: Aspirin
CAS Registry Number: 50-78-2
CAS Name: 2-(Acetyloxy)benzoic acid
Synonyms: salicylic acid acetate; 2-acetoxybenzoic acid; acetylsalicylic acid
Trademarks: Acylpyrin (Slovakofarma); Angettes (BMS); Asatard (Boehringer, Ing.); Aspro (Roche); Cardioaspirin (Bayer); Cardiprin (Reckitt Benckiser); Cemirit (Bayer); Claragine (Nicholas); Ecotrin (GSK); Empirin (GSK); Encaprin (Procter & Gamble); Rhonal (Aventis); Solprin (Reckitt Benckiser)
Molecular Formula: C9H8O4
Molecular Weight: 180.16
Percent Composition: C 60.00%, H 4.48%, O 35.52%
Literature References: Prepn: C. Gerhardt, Ann. 87, 149 (1853). Manuf from salicylic acid and acetic anhydride: Faith, Keyes & Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 117-120. Crystallization from acetone: Hamer, Phillips, US 2890240 (1959 to Monsanto). Novel process involving distillation: Edmunds, US 3235583 (1966 to Norwich Pharm.). Crystal structure: P. J. Wheatley, J. Chem. Soc. (Suppl.) 1964, 6036. Characterization of a second polymorphic form: P. Vishweshwar et al., J. Am. Chem. Soc. 127, 16802 (2005). Toxicity data: E. R. Hart, J. Pharmacol. Exp. Ther. 89, 205 (1947). Evaluation as a risk factor in Reye's syndrome: P. J. Waldman et al., J. Am. Med. Assoc. 247, 3089 (1982). Review of clinical trials in prevention of myocardial infarction and stroke: P. C. Elwood, Drugs 28, 1-5 (1984). Symposium on aspirin therapy: Am. J. Med. 74, no. 6A, 1-109 (1983). Clinical trials in prevention of colorectal cancer: R. S. Sandler et al., N. Engl. J. Med. 348, 883 (2003); J. A. Baron et al., ibid. 891. Comprehensive description: K. Florey, Anal. Profiles Drug Subs. 8, 1-46 (1979). Monograph: M. J. H. Smith, P. K. Smith, The Salicylates (Interscience, New York, 1966) 313 pp. Book: Acetylsalicylic Acid, H. J. M. Barnett et al., Eds. (Raven, New York, 1982) 278 pp.
Properties: Monoclinic tablets or needle-like crystals. d 1.40. mp 135° (rapid heating); the melt solidifies at 118°. uv max (0.1N H2SO4): 229 nm (E1%1cm 484); (CHCl3): 277 nm (E1%1cm 68). Is odorless, but in moist air it is gradually hydrolyzed into salicylic and acetic acids and acquires the odor of acetic acid. Stable in dry air. pK (25°) 3.49. One gram dissolves in 300 ml water at 25°, in 100 ml water at 37°, in 5 ml alcohol, 17 ml chloroform, 10-15 ml ether. Less soluble in anhydr ether. Decomp by boiling water or when dissolved in solns of alkali hydroxides and carbonates. Inorganic salts of acetylsalicylic acid are soluble in water (esp the Ca salt, q.v.), but are decomposed quickly. LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart).
Melting point: mp 135° (rapid heating)
pKa: pK (25°) 3.49
Absorption maximum: uv max (0.1N H2SO4): 229 nm (E1%1cm 484); (CHCl3): 277 nm (E1%1cm 68)
Density: d 1.40
Toxicity data: LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart)
 
Derivative Type: Guaiacol ester
CAS Registry Number: 55482-89-8
Synonyms: Guacetisal
Trademarks: Guaiaspir (Lampugnani)
Molecular Formula: C16H14O5
Molecular Weight: 286.28
Percent Composition: C 67.13%, H 4.93%, O 27.94%
 
Derivative Type: Methyl ester see Methyl Acetylsalicylate
 
Derivative Type: Phenyl ester see Phenyl Acetylsalicylate
 
CAUTION: Potential symptoms of overexposure are increased blood clotting time; nausea, vomiting; liver, kidney injury. Direct contact may cause eye, skin and upper respiratory irritation. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 6.
Therap-Cat: Analgesic; antipyretic; anti-inflammatory; antithrombotic.
Therap-Cat-Vet: Analgesic; antipyretic; anti-inflammatory; antithrombotic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic; Antithrombotic.