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CAS No 50-78-2 , 2-acetyloxybenzoic acid

  • Name: 2-acetyloxybenzoic acid
  • Synonyms: Acetosal; Acylpyrin;2-acetyloxybenzoic acid; Polopiryna; Ecotrin; Acenterine; Colfarit; 2-Acetoxybenzoic acid;ACETYLSALICYLIC ACID;
  • CAS Registry Number:
  • Transport: UN 1851
  • Melting Point: 136-140 ºC
  • Flash Point: 250 ºC
  • Boiling Point: 140 C
  • Density: 1.35
  • Water Solubility: 3.3 G/L (20 ºC)
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 250 ºC
  • EINECS: 200-064-1
  • Molecular Weight: 180.15742
  • InchiKey: BSYNRYMUTXBXSQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
  • Risk Statements: S26;S36/37/39
  • Molecular Formula: C9H8O4
  • Molecular Structure:CAS No:50-78-2 2-acetyloxybenzoic acid
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50-78-2 ASPIRIN, USP

  • United States Carbomer, Inc. [Manufacturer]
  • Tel: 858-552-0992/ (800) 239-7129
  • Fax: 858-552-0999
  • Address: PO Box 261026-1026
    San Diego, CA 92196 null,nullUnited States
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50-78-2 Aspirin

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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50-78-2 ASPIRIN

  • China ORICHEM INTERNATIONAL LTD. [Manufacturer, Trading Company]
  • Tel: 86-0571-85270505
  • Fax: 86-0571-85270303
  • Address: FLAT E,16/F,1 HUAZHE PLAZA,HANGZHOU, null,nullChina
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50-78-2 Acetylsalicylic acid

  • Acetylsalicylic acid
  • Norway Chiron AS [Manufacturer]
  • Tel: +47-73 87 44 90
  • Fax: +47-73 87 44 99
  • Address: Stiklestadveien 1N-7041 TrondheimNORWAY Trondheim,nullNorway
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50-78-2 ACETYLSALICYLIC ACID

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
  • Fax: +86 592 2680237
  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
    No.9 Hubin West Rd.,
    Xiamen China. null,nullChina
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50-78-2 Acetylsalicylic Acid

  • Acetylsalicylic Acid, 99%
  • China Tianjin Pharmacn Science Co., Ltd. [Manufacturer]
  • Tel: 86-22-23359620/ 86-13612042162 (mobile)
  • Fax: 86-22-23359620
  • Address: 1006 Sinochem Building, 707 Lianmeng RD, Shijiazhuang 050061, Hebei, China null,nullChina
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50-78-2 Aspirin

  • China TaiZhou HiKong Chemical Co., Ltd. null
  • Tel: +86-18967213045,13957694715
  • Fax: +86-(580)-6033180,6034626
  • Address: Taizhou Economic Technical Development Zone, Taizhou, Zhejiang 318000, null,nullChina
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50-78-2 Acetylsalicylic acid

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50-78-2 Acetylsalicylic acid

  • China KINFON PHARMACEUTICAL AND CHEMICAL CO.LTD [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: +86-23-8650081
  • Fax: +86-23-8650081
  • Address: 7F,Commercial Building, No.3 Nanping West Road,Nan null,nullChina
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50-78-2 Aspirin

  • China Qingdao Chinaoil Co., Ltd null
  • Fax: +86-532-85713888 85723888
  • Address: 22/F,Golden Light Tower,No.56, Xianggang Zhong Road, Qingdao 266071, China null,nullChina
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References of 2-acetyloxybenzoic acid
Title: Aspirin
CAS Registry Number: 50-78-2
CAS Name: 2-(Acetyloxy)benzoic acid
Synonyms: salicylic acid acetate; 2-acetoxybenzoic acid; acetylsalicylic acid
Trademarks: Acylpyrin (Slovakofarma); Angettes (BMS); Asatard (Boehringer, Ing.); Aspro (Roche); Cardioaspirin (Bayer); Cardiprin (Reckitt Benckiser); Cemirit (Bayer); Claragine (Nicholas); Ecotrin (GSK); Empirin (GSK); Encaprin (Procter & Gamble); Rhonal (Aventis); Solprin (Reckitt Benckiser)
Molecular Formula: C9H8O4
Molecular Weight: 180.16
Percent Composition: C 60.00%, H 4.48%, O 35.52%
Literature References: Prepn: C. Gerhardt, Ann. 87, 149 (1853). Manuf from salicylic acid and acetic anhydride: Faith, Keyes & Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 117-120. Crystallization from acetone: Hamer, Phillips, US 2890240 (1959 to Monsanto). Novel process involving distillation: Edmunds, US 3235583 (1966 to Norwich Pharm.). Crystal structure: P. J. Wheatley, J. Chem. Soc. (Suppl.) 1964, 6036. Characterization of a second polymorphic form: P. Vishweshwar et al., J. Am. Chem. Soc. 127, 16802 (2005). Toxicity data: E. R. Hart, J. Pharmacol. Exp. Ther. 89, 205 (1947). Evaluation as a risk factor in Reye's syndrome: P. J. Waldman et al., J. Am. Med. Assoc. 247, 3089 (1982). Review of clinical trials in prevention of myocardial infarction and stroke: P. C. Elwood, Drugs 28, 1-5 (1984). Symposium on aspirin therapy: Am. J. Med. 74, no. 6A, 1-109 (1983). Clinical trials in prevention of colorectal cancer: R. S. Sandler et al., N. Engl. J. Med. 348, 883 (2003); J. A. Baron et al., ibid. 891. Comprehensive description: K. Florey, Anal. Profiles Drug Subs. 8, 1-46 (1979). Monograph: M. J. H. Smith, P. K. Smith, The Salicylates (Interscience, New York, 1966) 313 pp. Book: Acetylsalicylic Acid, H. J. M. Barnett et al., Eds. (Raven, New York, 1982) 278 pp.
Properties: Monoclinic tablets or needle-like crystals. d 1.40. mp 135° (rapid heating); the melt solidifies at 118°. uv max (0.1N H2SO4): 229 nm (E1%1cm 484); (CHCl3): 277 nm (E1%1cm 68). Is odorless, but in moist air it is gradually hydrolyzed into salicylic and acetic acids and acquires the odor of acetic acid. Stable in dry air. pK (25°) 3.49. One gram dissolves in 300 ml water at 25°, in 100 ml water at 37°, in 5 ml alcohol, 17 ml chloroform, 10-15 ml ether. Less soluble in anhydr ether. Decomp by boiling water or when dissolved in solns of alkali hydroxides and carbonates. Inorganic salts of acetylsalicylic acid are soluble in water (esp the Ca salt, q.v.), but are decomposed quickly. LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart).
Melting point: mp 135° (rapid heating)
pKa: pK (25°) 3.49
Absorption maximum: uv max (0.1N H2SO4): 229 nm (E1%1cm 484); (CHCl3): 277 nm (E1%1cm 68)
Density: d 1.40
Toxicity data: LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart)
 
Derivative Type: Guaiacol ester
CAS Registry Number: 55482-89-8
Synonyms: Guacetisal
Trademarks: Guaiaspir (Lampugnani)
Molecular Formula: C16H14O5
Molecular Weight: 286.28
Percent Composition: C 67.13%, H 4.93%, O 27.94%
 
Derivative Type: Methyl ester see Methyl Acetylsalicylate
 
Derivative Type: Phenyl ester see Phenyl Acetylsalicylate
 
CAUTION: Potential symptoms of overexposure are increased blood clotting time; nausea, vomiting; liver, kidney injury. Direct contact may cause eye, skin and upper respiratory irritation. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 6.
Therap-Cat: Analgesic; antipyretic; anti-inflammatory; antithrombotic.
Therap-Cat-Vet: Analgesic; antipyretic; anti-inflammatory; antithrombotic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic; Antithrombotic.