Home > Name List By other > (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3, 5-diiodophenyl]propanoic acid Switzerland

CAS No 51-48-9 , (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,
5-diiodophenyl]propanoic acid Search by region : Switzerland

  • Name: (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,
    5-diiodophenyl]propanoic acid
  • Synonyms: Thyrax; Tetraiodothyronine;L-thyroxine; Thyreoideum; Thyroxinal; synthroid; Thyroxine iodine; Thyratabs; levothyroxine;(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,
    5-diiodophenyl]propanoic acid; thyroxin;
  • CAS Registry Number:
  • Melting Point: 223 ºC (DEC.)
  • Flash Point: 302.3°C
  • Boiling Point: 576.3°Cat760mmHg
  • Density: 2.635g/cm3
  • Refractive index: 1.795
  • Alpha: -5 º (1N NAOH:ETOH 1:2)
  • Safety Statements: R20/21/22:Harmfulbyinhalation,incontactwithskinandifswallowed.;
  • Hazard Symbols: Xn:Harmful;
  • Flash Point: 302.3°C
  • EINECS: 200-101-1
  • Molecular Weight: 776.87002
  • InchiKey: XUIIKFGFIJCVMT-LBPRGKRZSA-N
  • InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)
    19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
  • Risk Statements: S24/25
  • Molecular Formula: C15H11I4NO4
  • Molecular Structure:CAS No:51-48-9 (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,<br />5-diiodophenyl]propanoic acid

Select to

51-48-9 T-3850 L-THYROXINE, FREE ACID

  • Switzerland Biosynth AG [Manufacturer]
  • Tel: +41 71 858 20 20/ 630.305.8400 (USA)
  • Fax: +41 71 858 20 30
  • Address: BIOSYNTH AG
    Rietlistrasse 4
    9422 Staad / Switzerland
    Phone: +41 (0)71 858 20 20
    Fax: +41 (0)71 858 20 30 null,nullSwitzerland
Contact Supplier

Select to

References of (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,
5-diiodophenyl]propanoic acid
Title: Thyroxine
CAS Registry Number: 51-48-9
CAS Name: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
Synonyms: (-)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]alanine; 3,5,3¢,5¢-tetraiodo-L-thyronine; levothyroxine; T4
Molecular Formula: C15H11I4NO4
Molecular Weight: 776.87
Percent Composition: C 23.19%, H 1.43%, I 65.34%, N 1.80%, O 8.24%
Literature References: One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone, TSH, q.v. Circulates in the serum bound to specific proteins, primarily thyroxine-binding globulin, transthyretin, and albumin. Deiodinated in peripheral tissues to the active metabolite, liothyronine, q.v. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia. Isoln from thyroid: E. C. Kendall, J. Am. Med. Assoc. 64, 2042 (1915); idem, J. Biol. Chem. 39, 125 (1919). Structure: C. R. Harington, Biochem. J. 20, 293, 300 (1926). Synthesis: C. R. Harington, G. Barger, ibid. 21, 169 (1927); of naturally occurring L-form: J. R. Chalmers et al., J. Chem. Soc. 1949, 3424; of isomers and racemate: L. G. Ginger, P. Z. Anthony, US 2889363; US 2889364 (both 1959 to Baxter Labs.). Direct determn in serum by RIA: J. C. Nelson, R. T. Tomel, Clin. Chem. 34, 1737 (1988). Comprehensive description of levothyroxine sodium: A. Post, R. J. Warren, Anal. Profiles Drug Subs. 5, 225-281 (1976). Review of pharmacology: E. Sypniewski, Ann. Thorac. Surg. 56, S2-S8 (1993); of therapeutic use: A. D. Toft, N. Engl. J. Med. 331, 174-180 (1994). Review of thyroid physiology: D. A. Fisher, Clin. Chem. 42, 135-139 (1996); R. R. Cavalieri, Thyroid 7, 177-181 (1997).
Properties: Crystals, dec 235-236°. [a]25546 -3.2° (0.66 g in 6.07 g of 0.5N NaOH and 13.03 g alc); [a]D20 -4.4° (3% in 0.13N NaOH in 70% EtOH).
Optical Rotation: [a]25546 -3.2° (0.66 g in 6.07 g of 0.5N NaOH and 13.03 g alc); [a]D20 -4.4° (3% in 0.13N NaOH in 70% EtOH)
 
Derivative Type: Sodium salt
CAS Registry Number: 55-03-8
Synonyms: Levothyroxine sodium
Trademarks: Eferox (Wyeth); Eltroxin (GSK); Euthyrox (Merck KGaA); Levaxin (Nycomed); Levothroid (Forest); Levothyrox (Merck-Cl¢enot); Levoxyl (Jones); Oroxine (GSK); Soloxine (Virbac); Synthroid (Knoll); Thyro-Tabs (VET A MIX)
Molecular Formula: C15H10I4NNaO4
Molecular Weight: 798.85
Percent Composition: C 22.55%, H 1.26%, I 63.54%, N 1.75%, Na 2.88%, O 8.01%
Properties: Occurs as the hydrate. Triclinic crystals or cream-colored powder. Odorless, tasteless, somewhat hygroscopic. d420 2.381. [a]D20 -4.4° (c = 3 in 70% ethanol). Soly in water (25°): about 15 mg/100 ml. Sol in mineral acids and in solns of alkali hydroxides and carbonates. More sol in alcohol. Very slightly sol in chloroform, ether. pH of a satd water soln: 8.35 to 9.35.
Optical Rotation: [a]D20 -4.4° (c = 3 in 70% ethanol)
Density: d420 2.381
 
Derivative Type: DL-Thyroxine
CAS Registry Number: 300-30-1
Properties: Needle-like crystals. Dec 231-233°. Insol in water, in alcohol, and in the other usual organic solvents, but in the presence of mineral acids or alkalies it dissolves in alcohol; sol in solns of the alkali hydroxides and in hot solns of the alkali carbonates.
 
Derivative Type: D-Thyroxine
CAS Registry Number: 51-49-0
Synonyms: Dextrothyroxine
Properties: Crystals, dec 237°. [a]21546 +2.97° (0.74 g in 6 g of 0.5N NaOH and 14 g of alcohol).
Optical Rotation: [a]21546 +2.97° (0.74 g in 6 g of 0.5N NaOH and 14 g of alcohol)
 
Derivative Type: D-Thyroxine sodium salt
CAS Registry Number: 137-53-1
Synonyms: Dextrothyroxine sodium
Trademarks: Choloxin (Knoll); Debetrol (Sanofi); Dethyrona (Abbott); Dextroid (Baxter); Dynothel (Henning); Eulipos (Boehringer, Mann.)
 
Therap-Cat: Thyroid hormone. Dextrothyroxine as antilipemic.
Therap-Cat-Vet: Thyroid hormone.
Keywords: Antihypothyroid; Thyroid Hormone.