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CAS No 51025-85-5 , Arbekacin

  • Name: Arbekacin
  • Synonyms: (2S)-4-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-[(2R,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butanamide;Arbekacin;
  • CAS Registry Number:
  • Density: 1.47 g/cm3
  • Refractive index: 1.634
  • Molecular Weight: 552.62
  • InChI: InChI=1/C22H44N6O10/c23-4-3-12(30)20(34)28-11-5-10(26)18(37-21-9(25)2-1-8(6-24)35-21)17(33)19(11)38-22-16(32)14(27)15(31)13(7-29)36-22/h8-19,21-22,29-33H,1-7,23-27H2,(H,28,34)/t8-,9+,10-,11+,12-,13+,14-,15+,16+,17-,18+,19-,21+,22+/m0/s1
  • Molecular Formula: C22H44N6O10
  • Molecular Structure:CAS No:51025-85-5 Arbekacin

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51025-85-5 Arbekacin

  • China Inter-Chemical Ltd. [Manufacturers]
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51025-85-5 Arbekacin

  • China Si Yi Chem-Pharm Co.,Ltd. [Manufacturers]
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  • Address: Chengdu, Sichuan, 611130 China Chengdu,SichuanChina
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References of Arbekacin
Title: Arbekacin
CAS Registry Number: 51025-85-5
CAS Name: O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1?6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-erythro-hexopyranosyl-(1?4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine
Synonyms: 1-N-[(S)-4-amino-2-hydroxybutyryl]dibekacin; 1-N-[(S)-4-amino-2-hydroxybutyryl]-3￠,4￠-dideoxykanamycin B; HBK
Molecular Formula: C22H44N6O10
Molecular Weight: 552.62
Percent Composition: C 47.82%, H 8.03%, N 15.21%, O 28.95%
Literature References: Aminoglycoside antibiotic; derivative of kanamycin B, q.v. Prepn and antibacterial activity: S. Kondo et al., J. Antibiot. 26, 412 (1973); H. Umezawa et al., DE 2350169; eidem, US 4107424 (1974, 1978 both to Microbiochem. Res. Found.). Mechanism of action: N. Tanaka et al., Antimicrob. Agents Chemother. 24, 797 (1983); K. Matsunaga et al., J. Antibiot. 37, 596 (1984). Pharmacology: J. Stewens et al., Arzneim.-Forsch. 35, 1440 (1985); M. Kurebe et al., ibid. 36, 1511 (1986). Series of articles on antibacterial activity, pharmacology, pharmacokinetics, and clinical experience: Chemotherapy 34, Suppl. 1, pp 1-670 (1986). Review: Y. Kobayashi et al., Int. J. Antimicrob. Agents 5, 227-230 (1995).
 
Derivative Type: Sulfate
CAS Registry Number: 104931-87-5
Manufacturers' Codes: 1665-RB
Trademarks: Habekacin (Meiji Seika)
Molecular Formula: C22H44N6O10.H2SO4
Molecular Weight: 650.70
Percent Composition: C 40.61%, H 7.13%, N 12.92%, O 34.42%, S 4.93%
 
Derivative Type: Dicarbonate
Molecular Formula: C24H48N6O16
Molecular Weight: 676.67
Percent Composition: C 42.60%, H 7.15%, N 12.42%, O 37.83%
Properties: Colorless, crystalline powder, mp 178° (dec). [a]D24 +86.8° (c = 0.77 in water). LD50 i.v. in mice: >150 mg/kg (Umezawa, 1978).
Melting point: mp 178° (dec)
Optical Rotation: [a]D24 +86.8° (c = 0.77 in water)
Toxicity data: LD50 i.v. in mice: >150 mg/kg (Umezawa, 1978)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Aminoglycosides.