Home > Name List By 4 > 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan- 1-one

CAS No 52-86-8 , 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-
1-one

  • Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-
    1-one
  • Synonyms: Aloperidin;4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-
    1-one; Galoperidol; Aloperidolo; Aloperidol; Serenace; Eukystol; Brotopon;Haldol; Halopoidol;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 152 °C
  • Flash Point: 274
  • Boiling Point: 529
  • Density: 1.3 g/cm3 (20 C)
  • Safety Statements: R60;R61;R25;R36/37/38;R43
  • Hazard Symbols: T: Toxic;
  • Flash Point: 274
  • EINECS: 200-155-6
  • Molecular Weight: 375.864223
  • InchiKey: LNEPOXFFQSENCJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-
    2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
  • Risk Statements: S53;S26;S36/37/39;S45
  • Molecular Formula: C21H23ClFNO2
  • Molecular Structure:CAS No:52-86-8 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-<br />1-one
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52-86-8 HALOPERIDOL

  • HALOPERIDOL, BP/USP
  • India J.INC. [Manufacturer]
  • Tel: +91 79 30071152, 30071190, 30071175, 30071153
  • Fax: +91 79 30071176, 26574630
  • Address: # 95, Rangwala Towers, Law garden, Ellisbridge, Ahmedabad 380006, Gujarat State, India. 380006 AhmedabadINDIA Ahmedabad,nullIndia
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52-86-8 Haloperidol

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52-86-8 Haloperidol

  • China Hangzhou Pharma & Chem Co.,Ltd. [Manufacturers]
  • Tel: +86-571-87040515
  • Fax: +86-571-87214761
  • Address: Rm.1201,QinglianBldg.No,139QingchunRd,HangzhouCity,Zhejiang,China Hangzhou,ZhejiangChina
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52-86-8 HALOPERIDOL

  • United States EJY Tech, Inc. [Manufacturer]
  • Tel: 301-526-7059
  • Fax: 301-561-6521
  • Address: 9430 Key West Avenue
    Suite 220
    Rockville , MD 20850 null,nullUnited States
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52-86-8 Haloperidol

  • India Biokemix [Importer/Exporter]
  • Tel: +91-(40)-6613 6366
  • Fax: +91-(40)-6683 6366
  • Address: Kanchan, 10, Umanagar, Begumpet, Hyderabad, Andhra Pradesh 500016, Manchester,nullIndia
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52-86-8 HALOPERIDOL-D4

  • Canada SynFine Research Inc. [Manufacturer]
  • Tel: 905-737-2702
  • Fax: 905-737-6299
  • Address: SynFine Research Inc.
    P.O. Box 433 ? Station A
    Richmond Hill, ON L4C 4Y8
    Canada null,nullCanada
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52-86-8 Haloperidol

  • China Luna Chemicals Co.,Ltd. null
  • Fax: +86-571-85775960
  • Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China null,nullChina
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52-86-8 HALOPERIDOL

  • Canada TLC PharmaChem., Inc. [Manufacturer]
  • Tel: 905-760-1098
  • Fax: 905-760-2098
  • Address: TLC PharmaChem., Inc.
    5-150 Connie Crescent
    Concord, Ontario
    L4K 1L9, Canada null,nullCanada
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52-86-8 Haloperidol

  • China ZHEJIANG HOLYPHARM BIOTECH CO.,LTD [Manufacturers]
  • Tel: 86-533-8585678
  • Fax: 86-57187357695
  • Address: Room C 13th Floor, West Wing International Garden, No.160 Tianmushan Road, Xihu District, Hangzhou City, China null,nullChina
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52-86-8 HALOPERIDOL

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
    H4P 2R2 null,nullCanada
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References of 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-
1-one
Title: Haloperidol
CAS Registry Number: 52-86-8
CAS Name: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Synonyms: 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4¢-fluorobutyrophenone; 4¢-fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone; 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine
Manufacturers' Codes: R-1625
Trademarks: Aloperidin; Bioperidolo (Firma); Brotopon (Pfizer Taito); Dozic (Rosemont); Einalon S (Kodama); Eukystol (Merckle); Haldol (McNeil); Halosten (Shionogi); Keselan (Sumitomo); Linton (Yoshitomi); Peluces (Isei); Serenace (Searle); Serenase (Lusofarmaco); Sigaperidol (Dumex)
Molecular Formula: C21H23ClFNO2
Molecular Weight: 375.86
Percent Composition: C 67.11%, H 6.17%, Cl 9.43%, F 5.05%, N 3.73%, O 8.51%
Literature References: Prepn: P. A. J. Janssen et al., J. Med. Pharm. Chem. 1, 281 (1959); P. A. J. Janssen, BE 577977 (1959), C.A. 54, 4630c (1960); idem, GB 895309; idem, US 3438991 (1962, 1969 both to Janssen). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971); A. J. Collins, M. Horlington, Br. J. Pharmacol. 37, 140 (1969). Metabolism in man: A. Forsman et al., Curr. Ther. Res. 21, 606 (1977). Comprehensive description: C. A. Janicki, C. Y. Ko, Anal. Profiles Drug Subs. 9, 341-369 (1980). Review of pharmacology and therapeutic efficacy of decanoate in psychosis: R. Beresford, A. Ward, Drugs 33, 31-49 (1987).
Properties: Crystals, mp 148.0-149.4°. uv max (9:1 0.1M HCl:methanol): 247, 221 nm (e 13300, 15000). pKa 8.3. Soly in water: 1.4 mg/100 ml. Freely sol in chloroform, methanol, acetone, benzene, dil acids. LD50 orally in rats: 165 mg/kg (Goldenthal); i.p. in mice: 60 mg/kg (Collins, Horlington).
Melting point: mp 148.0-149.4°
pKa: pKa 8.3
Absorption maximum: uv max (9:1 0.1M HCl:methanol): 247, 221 nm (e 13300, 15000)
Toxicity data: LD50 orally in rats: 165 mg/kg (Goldenthal); i.p. in mice: 60 mg/kg (Collins, Horlington)
 
Derivative Type: Hydrochloride
CAS Registry Number: 1511-16-6
Molecular Formula: C21H23ClFNO2.HCl
Molecular Weight: 412.33
Percent Composition: C 61.17%, H 5.87%, Cl 17.20%, F 4.61%, N 3.40%, O 7.76%
Properties: Crystals, mp 226-227.5°. Soly in water: 300 mg/100 ml.
Melting point: mp 226-227.5°
 
Derivative Type: Decanoate
CAS Registry Number: 74050-97-8
Manufacturers' Codes: KD-136
Trademarks: Haldol Decanoate (Janssen); Halomonth (Dainippon); Neoperidole (Kyowa Hakko)
Molecular Formula: C31H41ClFNO3
Molecular Weight: 530.11
Percent Composition: C 70.24%, H 7.80%, Cl 6.69%, F 3.58%, N 2.64%, O 9.05%
 
Therap-Cat: Antidyskinetic (in Gilles de la Tourette's disease); antipsychotic.
Keywords: Antidyskinetic; Antipsychotic; Butyrophenones.