Title: Pyridoxamine Dihydrochloride
CAS Registry Number: 524-36-7
CAS Name: 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride
Synonyms: 2-methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine dihydrochloride
Molecular Formula: C8H14Cl2N2O2
Molecular Weight: 241.11
Percent Composition: C 39.85%, H 5.85%, Cl 29.41%, N 11.62%, O 13.27%
Literature References: Synthesis and structure: Harris
et al., J. Biol. Chem. 154, 315 (1944);
J. Am. Chem. Soc. 66, 2088 (1944).
Properties: Platelets, mp 226-227° with dec. Soluble in water (approx 1 g/2 ml); sol in 95% alc (0.65 g/100 ml). Reasonably stable at room temp; shows no decompn in a few days at 60°. Liquefies on exposure to 80% relative humidity. pH of a 1% water soln 2.4. uv max (pH 1.94): 287.5 nm (E mol 91,000).
Melting point: mp 226-227° with dec
Absorption maximum: uv max (pH 1.94): 287.5 nm (E mol 91,000)
Derivative Type: Free base
Properties: Crystals from alc; mp 193-193.5°; sol in alc.
Melting point: mp 193-193.5°
Derivative Type: Pyridoxamine phosphate
Synonyms: 2-Methyl-3-hydroxy-4-aminomethyl-5-pyridylmethylphosphoric acid
Molecular Formula: C8H13N2O5P
Molecular Weight: 248.17
Percent Composition: C 38.72%, H 5.28%, N 11.29%, O 32.23%, P 12.48%
Literature References: Prepn in soln by autoclaving codecarboxylase with glutamic acid: McNutt, Snell,
J. Biol. Chem. 182, 557 (1950); prepn by direct phosphorylation of pyridoxamine in aq soln with phosphorus oxychloride: Heyl
et al., J. Am. Chem. Soc. 73, 3430 (1951).
