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CAS No 52468-60-7 , 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine

  • Name: 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
  • Synonyms: Flunarizin; Flufenal; Issium; Vertix;1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine; Flunarizina [INN-Spanish]; Fluvert; Zinasen;Sibelium; Flunarizinum [INN-Latin];
  • CAS Registry Number:
  • Density: 1.17 g/cm3
  • Refractive index: 1.606
  • EINECS: 257-937-5
  • Molecular Weight: 404.494846
  • InchiKey: SMANXXCATUTDDT-QPJJXVBHSA-N
  • InChI: InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)
    30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+
  • Molecular Formula: C26H26F2N2
  • Molecular Structure:CAS No:52468-60-7 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
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52468-60-7 FLUNARIZINE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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52468-60-7 Flunarizine

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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52468-60-7 Flunarizine

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52468-60-7 flunarizine

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52468-60-7 FLUNARIZINE

  • China ORICHEM INTERNATIONAL LTD. [, Manufacturer, Trading Company]
  • Tel: 86-0571-85270505
  • Fax: 86-0571-85270303
  • Address: FLAT E,16/F,1 HUAZHE PLAZA,HANGZHOU, ,China
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52468-60-7 Flunarizine

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52468-60-7 Flunarizine

  • Hong kong LEO CHEMICAL (HONG KONG) CO., LTD [Manufacturer]
  • Tel: 86-519-85098858/ 86-519-85098877
  • Fax: 86-519-85098888/8889
  • Address: Hong Kong Office :
    LEO CHEMICAL (HONG KONG) CO., LTD
    MNJ2070, RM1602,
    OMEGA PLAZA, 32 DUNDAS STREET,
    MONKOK, KL, HONG KONG ,Hong kong
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52468-60-7 FLUNARIZINE DIHYDROCHLORIDE

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
    H4P 2R2 ,Canada
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52468-60-7 flunarizine

  • China SOGA ENTERPRISES ASIA GROUP [Manufacturers]
  • Tel: +86-633-8332928
  • Fax: +86-633-8352255
  • Address: No.1,Huanghai Yilu.Rizhao,Shandong ,ShandongChina
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52468-60-7 Flunarizine

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References of 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
Title: Flunarizine
CAS Registry Number: 52468-60-7
CAS Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine
Synonyms: (E)-1-[bis(p-fluorophenyl)-methyl]-4-cinnamylpiperazine; 1-cinnamyl-4-(di-p-fluorobenzhydryl)piperazine
Molecular Formula: C26H26F2N2
Molecular Weight: 404.49
Percent Composition: C 77.20%, H 6.48%, F 9.39%, N 6.93%
Literature References: Calcium channel blocker; fluorinated deriv of cinnarizine, q.v. Prepn: P. A. J. Janssen, DE 1929330 and FR 2014487; idem, US 3773939 (1970, 1970, 1973, all to Janssen). Pharmacology: L. K. Desmedt et al., Arzneim.-Forsch. 25, 1408 (1975); T. Godfraind, Eur. J. Pharmacol. 53, 273 (1979). Clinical studies: J. Schetz et al., Curr. Ther. Res. 23, 131 (1978); G. Rudofsky et al., Angiology 30, 479 (1979). Rheological effects in humans: J. D. Cree et al., ibid. 505. Mechanism of calcium blocking activity: T. Godfraind, Fed. Proc. 40, 2866 (1981). Clinical study in retinal vasculopathy: P. Nihard, Angiology 33, 37 (1982). Clinical trial in chronic cerebrovascular disorders: A. Agnoli et al., Int. J. Clin. Pharmacol. Res. 8, 189 (1988). Series of articles on absorption, distribution, excretion and metabolism: Arzneim.-Forsch. 33, 1135-1151 (1983). Review of pharmacology, toxicology and clinical studies: B. Holmes et al., Drugs 27, 6 (1984).
 
Derivative Type: Dihydrochloride
CAS Registry Number: 30484-77-6
Trademarks: Dinaplex (Sidus); Flugeral (Italfarmaco); Flunagen (Gentili); Flunarl (Kyowa Hakko); Fluxarten (SKB); Gradient (Polifarma); Issium (Lifepharma); Mondus (Labinca); Sibelium (Janssen)
Molecular Formula: C26H26F2N2.2HCl
Molecular Weight: 477.42
Percent Composition: C 65.41%, H 5.91%, F 7.96%, N 5.87%, Cl 14.85%
Properties: Crystals from a mixture of 2-propanol/ethanol, mp 251.5°.
Melting point: mp 251.5°
 
Therap-Cat: Vasodilator (cerebral and peripheral).
Keywords: Calcium Channel Blocker; Piperazine Derivatives; Vasodilator (Cerebral); Vasodilator (Peripheral).