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CAS No 54-31-9 , 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid

  • Name: 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
  • Synonyms: Furanthryl; Fuluvamide;4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid; Fusid; Errolon;Frusemide; Furosemid; Furantril; Lasix; Furanthril;
  • CAS Registry Number:
  • Transport: UN 1230 3/PG 2
  • Melting Point: 220 ºC
  • Density: 1.606
  • Water Solubility: Slightly soluble in water
  • Safety Statements: R61
  • Hazard Symbols: T: Toxic;
  • EINECS: 200-203-6
  • Molecular Weight: 330.74414
  • InchiKey: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21
    (14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
  • Risk Statements: S22;S36/37/39;S53;S45
  • Molecular Formula: C12H11ClN2O5S
  • Molecular Structure:CAS No:54-31-9 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid

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References of 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
Title: Furosemide
CAS Registry Number: 54-31-9
CAS Name: 5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid
Synonyms: 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid; 4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid; frusemide; fursemide
Manufacturers' Codes: LB-502
Trademarks: Aisemide; Beronald (Kowa); Desdemin (Vitacain); Discoid (Sagitta); Diural (Apothokermes); Dryptal (Berk); Durafurid (Durachemie); Errolon; Eutensin (Aventis); Frusetic (Unimed); Frusid (DDSA); Fulsix (Tatsumi); Fuluvamide (Mect); Furesis (BMS); Furo-Puren (Klinge-Nattermann); Furosedon (Santen); Hydro-rapid (Sanorania); Impugan (Dumex); Katlex (Iwaki); Lasilix (Aventis); Lasix (Aventis); Lowpston (Maruko); Macasirool (Hishiyama); Mirfat (Merckle); Nicorol (Lundbeck); Odemase (Azupharma); Oedemex (Mepha); Profemin (Yamanouchi); Rosemide (Ono); Rusyde (CP); Trofurit (Chinoin); Urex (Mochida)
Molecular Formula: C12H11ClN2O5S
Molecular Weight: 330.74
Percent Composition: C 43.58%, H 3.35%, Cl 10.72%, N 8.47%, O 24.19%, S 9.69%
Literature References: Prepn: K. Stürm et al., DE 1122541; eidem, US 3058882 (both 1962 to Hoechst). Molecular and crystal structure: J. Lamotte et al., Acta Crystallogr. B34, 1657 (1978). Review of pharmacokinetics: L. Z. Benet, J. Pharmacokinet. Biopharm. 7, 1-27 (1979); R. E. Cutler, A. D. Blair, Clin. Pharmacokinet. 4, 279-296 (1979). Pharmacodynamics and pharmacokinetics of a slow-release formulation in man: A. Ebihara et al., Arzneim.-Forsch. 33, 163 (1983). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: A. M. Al-Obaid et al., Anal. Profiles Drug Subs. 18, 153-193 (1989).
Properties: Crystals from aq ethanol, mp 206°. uv max (95% ethanol): 288, 276, 336 nm (E1%1cm 945, 588, 144); (0.1N NaOH): 226, 273, 336 nm (E1%1cm 1147, 557, 133). Slightly sol in water, chloroform, ether. Sol in acetone, methanol, DMF, aq solns above pH 8.0. Less sol in ethanol. Pharmaceut. Incompat: Calcium gluconate, ascorbic acid, tetracyclines, urea, epinephrine. LD50 orally in female, male rats: 2600, 2820 mg/kg (Goldenthal).
Melting point: mp 206°
Absorption maximum: uv max (95% ethanol): 288, 276, 336 nm (E1%1cm 945, 588, 144); (0.1N NaOH): 226, 273, 336 nm (E1%1cm 1147, 557, 133)
Toxicity data: LD50 orally in female, male rats: 2600, 2820 mg/kg (Goldenthal)
Therap-Cat: Diuretic; antihypertensive.
Therap-Cat-Vet: Diuretic.
Keywords: Antihypertensive; Sulfonamide Derivatives; Diuretic; Sulfonamide Derivatives.