Home > Name List By 3 > 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3, 6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one Hungary

CAS No 548-73-2 , 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,
6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one Search by region : Hungary

  • Name: 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,
    6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
  • Synonyms: Inapsine; Halkan; Dehydrobenzperidol; Properidol;3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,
    6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one;Droleptan; Sintosian; Sintodril; Dridol; Innovar;
  • CAS Registry Number:
  • Transport: 3249
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.269g/cm3
  • Refractive index: 1.613
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: °C
  • EINECS: 208-957-8
  • Molecular Weight: 379.427383
  • InchiKey: RMEDXOLNCUSCGS-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-
    15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,
    28)
  • Risk Statements: S36
  • Molecular Formula: C22H22FN3O2
  • Molecular Structure:CAS No:548-73-2 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,<br />6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one

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References of 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,
6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
Title: Droperidol
CAS Registry Number: 548-73-2
CAS Name: 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one
Synonyms: 1-[1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone; 1-[1-[4-(p-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone
Manufacturers' Codes: R-4749
Trademarks: Dehydrobenzperidol (Janssen); Dridol; Droleptan (Le Brun); Inapsine (McNeil)
Molecular Formula: C22H22FN3O2
Molecular Weight: 379.43
Percent Composition: C 69.64%, H 5.84%, F 5.01%, N 11.07%, O 8.43%
Literature References: Prepn: P. A. J. Janssen, J. F. Gardocki, US 3161645 (1964 to Janssen). Pharmacology and toxicity: J. Yelnosky et al., Toxicol. Appl. Pharmacol. 6, 37 (1964). Comprehensive description: C. A. Janicki, R. K. Gilpin, Anal. Profiles Drug Subs. 7, 171-192 (1978).
 
Derivative Type: Hydrate
Properties: Crystals, mp 145-146.5°. uv max (9:1, 0.1M HCl:methanol): 245, 280 nm (e 15600, 7500). Soly at 25° (g/100 ml): chloroform 40; DMF 17; benzene 0.55; methanol 0.41; ethanol 0.34; ether 0.24; 0.1M HCl 0.15; water <0.001. pKa 7.64. Heat and light sensitive. LD50 in mice (mg/kg): 125 s.c.; 43 i.v. (Yelnosky).
Melting point: mp 145-146.5°
pKa: pKa 7.64
Absorption maximum: uv max (9:1, 0.1M HCl:methanol): 245, 280 nm (e 15600, 7500)
Toxicity data: LD50 in mice (mg/kg): 125 s.c.; 43 i.v. (Yelnosky)
 
NOTE: Ingredient of Thalamonal, Innovar.
Therap-Cat: Antipsychotic.
Therap-Cat-Vet: Tranquilizer.
Keywords: Antipsychotic; Butyrophenones.