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CAS No 55-63-0 , 1,3-dinitrooxypropan-2-yl nitrate

  • Name: 1,3-dinitrooxypropan-2-yl nitrate
  • Synonyms: Glyceryl trinitrate;Nitrostat; Minitran; Nitro-dur;1,3-dinitrooxypropan-2-yl nitrate; Trinitroglycerin; Nitrospan; Transderm Nitro; Nitroglycerine;
  • CAS Registry Number:
  • Transport: UN 0143/0144/1204/3064
  • Melting Point: 144 - 146
  • Density: 1.671 g/cm3
  • Refractive index: 1.4777 (7.7 C)
  • Safety Statements: Human poison by an unspecified route. Poison experimentally by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A skin irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. It can cause respiratory difficulties and death due to respiratory paralysis by ingestion. The acute symptoms of nitroglycerin poisoning are headaches, nausea, vomiting, abdominal cramps, convulsions, methemoglobinemia, circulatory collapse and reduced blood pressure, excitement, vertigo, fainting, respiratory rales, and cyanosis. Toxic effects may occur by ingestion, inhalation of dust, or absorption through intact skin. Human systemic effects by intravenous route: encephalitis, miosis, corneal damage. Used as a vasodilator and as an explosive.A very dangerous fire hazard when exposed to heat, flame, or by spontaneous chemical reaction. A severe explosion hazard when shocked or exposed to O3, heat, or flame. Nitroglycerin is a powerful explosive, very sensitive to mechanical shock, heat, or UV radiation. Small quantities of it can readily be detonated by a hammer blow on a hard surface, particularly when it has been absorbed in filter paper. It explodes when heated to 215°C. Frozen nitroglycerin is somewhat less sensitive than the liquid. However, a half-thawed or partially thawed mixture is more sensitive than either one. When heated to decomposition it emits toxic fumes of NOx. See also EXPLOSIVES, HIGH; and DYNAMITE.Analytical Methods:   For occupational chemical analysis use OSHA: #43 or NIOSH: Nitroglycerin and Ethylene Glycol Dinitrate, 2507.
  • Hazard Symbols: Severe explosion risk, highly sensitive to shock and heat. Toxic by ingestion, inhalation, and skin absorption. TLV: 0.05 ppm. Toxic by skin absorption.
  • EINECS: 200-240-8
  • Molecular Weight: 227.0865
  • InchiKey: SNIOPGDIGTZGOP-UHFFFAOYSA-N
  • InChI: InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2
  • Risk Statements: 11
  • Molecular Formula: C3H5N3O9
  • Molecular Structure:CAS No:55-63-0 1,3-dinitrooxypropan-2-yl nitrate
References of 1,3-dinitrooxypropan-2-yl nitrate
Title: Nitroglycerin
CAS Registry Number: 55-63-0
CAS Name: 1,2,3-Propanetriol trinitrate
Synonyms: glyceryl trinitrate; glycerol nitric acid triester; nitroglycerol; trinitroglycerol; glonoin; trinitrin; blasting gelatin; blasting oil; S.N.G.
Trademarks: Adesitrin (Pharmacia); Anginine (Sigma); Aquo-Trinitrosan (Merck KGaA); Cordipatch (Schwarz); Corditrine (Aventis); Deponit (Schwarz); Diafusor (Fabre); Discotrine (3M Pharma); Lenitral (Besins-Iscovesco); Millisrol (Nippon Kayaku); Minitran (3M Pharma); Nitradisc (Pfizer); Nitro-Bid (Altana); Nitrocine (Schwarz); Nitrocontin (Mundipharma); Nitroderm (Novartis); Nitro-Dur (Schering-Plough); Nitrogard (Forest); Nitroglin (Stada); Nitroglyn (Bradley); Nitrolingual (Pohl); Nitromex (Alpharma); Nitronal (Merck KGaA); Nitrong (Lavipharm); Nitrostat (Warner-Lambert); Nitrosylon (Abbott); Percutol (Pliva); Perlinganit (Schwarz); Rectogesic (Strakan); Suscard (Forest); Sustac (Forest); Transderm-Nitro (Novartis); Transiderm-Nitro (Novartis); Tridil (BMS); Trinitrosan (Merck KGaA)
Molecular Formula: C3H5N3O9
Molecular Weight: 227.09
Percent Composition: C 15.87%, H 2.22%, N 18.50%, O 63.41%
Literature References: Nitric oxide donor that induces vasodilation. Prepn: Sobrero, Ann. 64, 398 (1847); Williamson, Ann. 92, 305 (1854). Review of the early literature: J. W. Lawrie, Glycerol and the Glycols (New York, 1928). Review of chemistry and biochemistry: F. J. DiCarlo, Drug Metab. Rev. 4, 1-38 (1975). Review of mechanism of action: S. F. Vatner, G. R. Heyndrickx, Handb. Exp. Pharmakol. 40, 131-161 (1975). Molecular mechanism of nitric oxide release: Z. Chen et al., Proc. Natl. Acad. Sci. USA 99, 8306 (2002). Review of the first hundred years: J. R. Parratt, J. Pharm. Pharmacol. 31, 801-809 (1979). Comprehensive description: E. F. McNiff et al., Anal. Profiles Drug Subs. 9, 519-541 (1980). Symposium on nitroglycerin therapy, perspectives and mechanisms: Am. J. Med. 74, no. 6B, 1-94 (1983). Review of pharmacology and clinical studies of intravenous administration in heart disease: E. M. Sorkin et al., Drugs 27, 45 (1984). Clinical trial in treatment of anal fissures: J. H. Scholefield et al., Gut 52, 264 (2005).
Properties: Pale yellow, oily liquid. Sweet burning taste. Produces headache on tasting. Explodes on rapid heating or on concussion. Crystallizes in 2 forms: labile form, mp 2.8°; stable form, mp 13.5°. d1515 1.599; d44 1.6144; d415 1.6009; d425 1.5918. nD15 1.474. Begins to dec at 50-60°, appreciably volatile at 100°, evolves nitrous yellow vapors at 135°, explodes at 218°. Vapor pressure at 20°: 0.00026 mm; at 93°: 0.31 mm. One gram dissolves in 800 ml water, in 4 g ethanol, in 18 g methanol, in 120 g carbon disulfide. Misc with ether, acetone, glacial acetic acid, ethyl acetate, benzene, nitrobenzene, pyridine, chloroform, ethylene bromide, dichloroethylene. Sparingly sol in petr ether, liq petrolatum, glycerol. Heat of combustion: 1580 cal/g. On explosion harmless gases are produced: 4C3H5(ONO2)3 ? 12CO2 + 10H2O + 6N2 + O2.
Melting point: mp 2.8°; mp 13.5°
Index of refraction: nD15 1.474
Density: d1515 1.599; d44 1.6144; d415 1.6009; d425 1.5918
 
Derivative Type: Spirit of Glyceryl Trinitrate
Synonyms: Spirit of nitroglycerin; spirit of glonoin
Literature References: An alcoholic soln contg 1.0-1.1% glyceryl trinitrate.
Properties: Colorless, clear liquid. d 0.814-0.820. Miscible with alcohol, chloroform, ether; 1 ml dissolves in 6 ml almond oil; very slightly sol in water; miscible with chloroform, ether.
Density: d 0.814-0.820
 
CAUTION: Potential symptoms of overexposure by percutaneous or respiratory absorption are throbbing headache, dizziness, nausea, vomiting, abdominal pain; hypotension; flushing; palpitations; methemoglobinemia; delerium, CNS depression; angina; cyanosis; coma. Direct contact may cause skin irritation. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 228; Patty's Industrial Hygiene and Toxicology vol. 2B, G. D. Clayton, F. E. Clayton, Eds. (Wiley-Interscience, New York, 4th ed., 1994) pp 1064-1067.
Use: Manuf of dynamite (75% nitroglycerol, 24.5% diatomaceous earth, 0.5% sodium carbonate), smokeless powders and blasting gelatin; in rocket propellants.
Therap-Cat: Antianginal; vasodilator (coronary). Topically in treatment of anal fissures.
Keywords: Antianginal; Vasodilator (Coronary).