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CAS No 552-94-3 , 2-(2-hydroxybenzoyl)oxybenzoic acid

  • Name: 2-(2-hydroxybenzoyl)oxybenzoic acid
  • Synonyms: sasapyrine; Diplosal; Diacesal; Saloxium;Salsalate;2-(2-hydroxybenzoyl)oxybenzoic acid; Disalyl; Sasapyrinum; Disalicylic acid; Disalcid; Salicylsalicylic acid;
  • CAS Registry Number:
  • Melting Point: 148-151 ºC
  • Density: 1.404g/cm3
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 209-027-4
  • Molecular Weight: 258.2262
  • InchiKey: WVYADZUPLLSGPU-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)
    17/h1-8,15H,(H,16,17)
  • Risk Statements: S26;S37/39
  • Molecular Formula: C14H10O5
  • Molecular Structure:CAS No:552-94-3 2-(2-hydroxybenzoyl)oxybenzoic acid

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References of 2-(2-hydroxybenzoyl)oxybenzoic acid
Title: Salsalate
CAS Registry Number: 552-94-3
CAS Name: 2-Hydroxybenzoic acid 2-carboxyphenyl ester
Synonyms: disalicylic acid; salicylic acid bimolecular ester; salicyloxysalicylic acid; salicylsalicylic acid
Manufacturers' Codes: NSC-49171
Trademarks: Disalcid (3M); Disalgesic (3M); Mono-Gesic (Central); Salflex (Carnrick)
Molecular Formula: C14H10O5
Molecular Weight: 258.23
Percent Composition: C 65.12%, H 3.90%, O 30.98%
Literature References: Nonacetylated aspirin analog. Prepn: DE 211403 and DE 214044 (1909, both to Boehringer, Mann.), Frdl. 9, 928 and C.A. 4, 368 (1910); W. Baker et al., J. Chem. Soc. 1951, 201. Metabolism: S. M. Dromgoole et al., J. Pharm. Sci. 73, 1657 (1984). Clinical evaluation in arthritis: T. C. McPherson, Clin. Ther. 6, 388 (1984). Mechanism of action studies: C. A. Divincenzo, F. R. Venezio, Curr. Ther. Res. 42, 720 (1987). HPLC determn in plasma and urine: L. I. Harrison et al., J. Pharm. Sci. 69, 1268 (1980). Review of chemistry, pharmacokinetics, safety and clinical efficacy: P. T. Singleton, Clin. Ther. 3, 80-102 (1980).
Properties: Crystals from benzene. mp 148-149°. Practically insol in water but gradually hydrolyzed by it into 2 mols of salicylic acid. Sol in alc, ether; sparingly sol in benzene.
Melting point: mp 148-149°
Therap-Cat: Analgesic, anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives.