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CAS No 56741-95-8 , 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one

  • Name: 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one
  • Synonyms: 56741-95-8; 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidinone; Bropiriminum [Latin]; ABPP;2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine;2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one;
  • CAS Registry Number:
  • Flash Point: 189.5°C
  • Boiling Point: 389.7°Cat760mmHg
  • Density: 1.74g/cm3
  • Refractive index: 1.715
  • Safety Statements: Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx, Br−.
  • Flash Point: 189.5°C
  • Molecular Weight: 266.09402
  • InchiKey: CIUUIPMOFZIWIZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H8BrN3O/c11-7-8(6-4-2-1-3-5-6)13-10(12)14-9(7)15/h1-5H,(H3,
    12,13,14,15)
  • Molecular Formula: C10H8BrN3O
  • Molecular Structure:CAS No:56741-95-8 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one

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References of 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one
Title: Bropirimine
CAS Registry Number: 56741-95-8
CAS Name: 2-Amino-5-bromo-6-phenyl-4(1H)-pyrimidinone
Synonyms: 5-bromo-6-phenylisocytosine; 5-bromo-2,3-dihydro-2-imino-6-phenyl-4[1H]-pyrimidinone; ABPP
Manufacturers' Codes: U-54461
Trademarks: Remisar (Pharmacia & Upjohn)
Molecular Formula: C10H8BrN3O
Molecular Weight: 266.09
Percent Composition: C 45.14%, H 3.03%, Br 30.03%, N 15.79%, O 6.01%
Literature References: Biological response modifier; induces production of a-interferon. Prepn: T. B. Brown, M. F. G. Stevens, J. Chem. Soc. Perkin Trans. 1 1975, 1023; M. F. G. Stevens et al., Anti-Cancer Drug Des. 10, 215 (1995). Antiviral and interferon-inducing effects: D. A. Stringfellow et al., J. Interferon Res. 1, 1 (1980). Structure-activity study: H. I. Skulnick et al., J. Med. Chem. 28, 1864 (1985). Crystal structure and 1H-NMR: M. F. G. Stevens et al., Anti-Cancer Drug Des. 10, 203 (1995). Review of clinical studies in bladder cancer: M. F. Sarosdy, Ann. N.Y. Acad. Sci. 685, 301-308 (1993).
Properties: Crystals from 2-ethoxyethanol, mp 285-287° (Stevens). Also reported as crystals from aq ethanol, mp 246-248° (Brown, Stevens). Tautomeric. pKa 3.18; 8.53. Soly in water: >200 mg/ml at pH 13; <40 mg/ml at pH 3-7.
Melting point: mp 285-287° (Stevens); mp 246-248° (Brown, Stevens)
pKa: pKa 3.18; 8.53
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Immunomodulators; Immunomodulator.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.