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CAS No 57-43-2 , 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione

  • Name: 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione
  • Synonyms: Amytal; Barbamil; Barbamyl; Eunoctal; Talamo; Isomytal; Amobarbitone;Amylobarbitone; Pentymal;5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 156-158 ºC
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.069 g/cm3
  • Refractive index: 1.4584
  • Water Solubility: <0.1 G/100 ML AT 18.5 ºC
  • Safety Statements: A poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. See also BARBITURATES. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: °C
  • EINECS: 200-330-7
  • Molecular Weight: 226.27222
  • InchiKey: VIROVYVQCGLCII-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,
    4-6H2,1-3H3,(H2,12,13,14,15,16)
  • Molecular Formula: C11H18N2O3
  • Molecular Structure:CAS No:57-43-2 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione
References of 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione
Title: Amobarbital
CAS Registry Number: 57-43-2
CAS Name: 5-Ethyl-5-(3-methylbutyl)-2,4,6-(1H,3H,5H)-pyrimidinetrione
Synonyms: 5-ethyl-5-isopentylbarbituric acid; 5-ethyl-5-isoamylbarbituric acid; barbamil; amylobarbitone; 5-isoamyl-5-ethylbarbituric acid; pentymal
Trademarks: Amal (Knoll); Amasust (Knoll); Amytal (Flynn); Eunoctal (Houd?; Isomytal (Nippon Shinyaku); Mylodorm (G.P.); Sednotic (Dista); Stadadorm (Stada)
Molecular Formula: C11H18N2O3
Molecular Weight: 226.27
Percent Composition: C 58.39%, H 8.02%, N 12.38%, O 21.21%
Literature References: Prepn: US 1514573 (1924). Metabolism: Frey, Magnussen, Arzneim.-Forsch. 16, 612 (1966). Toxicity data: K. Irrgang, ibid. 15, 688 (1965). Comprehensive description: N. A. A. Mian et al., Anal. Profiles Drug Subs. 19, 27-58 (1990).
Properties: Slightly bitter crystals, mp 156-158°. One gram dissolves in 1300 ml water, in 5 ml alc, in 17 ml chloroform, in 6 ml ether. Freely sol in benzene; sol in alkaline solns. Insol in petr ether, aliphatic hydrocarbons. A satd aq soln is acid to litmus paper. Dissolves in aq solns of alkali hydroxides and carbonates. pH of a saturated soln in water about 5.6. pKa (25°C) 8.0. LD50 in mice (mg/kg): 212 s.c. (Irrgang).
Melting point: mp 156-158°
pKa: pKa (25°C) 8.0
Toxicity data: LD50 in mice (mg/kg): 212 s.c. (Irrgang)
 
Derivative Type: Sodium salt
CAS Registry Number: 64-43-7
Trademarks: Sodium Amytal (Flynn)
Molecular Formula: C11H17N2NaO3
Molecular Weight: 248.25
Percent Composition: C 53.22%, H 6.90%, N 11.28%, Na 9.26%, O 19.33%
Properties: Hygroscopic, friable granules of powder. Slightly bitter taste. Very soluble in water; sol in alcohol (1:1). Practically insol in ether.
 
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.12 and 1308.13.
Therap-Cat: Sedative, hypnotic.
Therap-Cat-Vet: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Barbituric Acid Derivatives.