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CAS No 57-66-9 , 4-(dipropylsulfamoyl)benzoic acid Search by region : Germany

  • Name: 4-(dipropylsulfamoyl)benzoic acid
  • Synonyms: Tubophan; Benuryl;Benemid;4-(dipropylsulfamoyl)benzoic acid; Probenemid; Probenecid acid; Prolongine; Probexin; Probecid; Benecid;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 194-196 ºC
  • Density: 1.221 g/cm3
  • Water Solubility: <0.1 G/100 ML AT 20 ºC
  • Safety Statements: R22;R40
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 200-344-3
  • Molecular Weight: 285.35926
  • InchiKey: DBABZHXKTCFAPX-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,
    18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
  • Risk Statements: S36/37
  • Molecular Formula: C13H19NO4S
  • Molecular Structure:CAS No:57-66-9 4-(dipropylsulfamoyl)benzoic acid

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57-66-9 PROBENECID; 98%

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany null,nullGermany
Contact Supplier

57-66-9 PROBENECID

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany null,nullGermany
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References of 4-(dipropylsulfamoyl)benzoic acid
Title: Probenecid
CAS Registry Number: 57-66-9
CAS Name: 4-[(Dipropylamino)sulfonyl]benzoic acid
Synonyms: p-(dipropylsulfamoyl)benzoic acid; p-(dipropylsulfamyl)benzoic acid
Trademarks: Benemid (Merck & Co.); Probecid (Astra); Proben (SCS)
Molecular Formula: C13H19NO4S
Molecular Weight: 285.36
Percent Composition: C 54.72%, H 6.71%, N 4.91%, O 22.43%, S 11.24%
Literature References: Prepn from p-carboxybenzenesulfonyl chloride and dipropylamine: C. S. Miller, US 2608507 (1952 to Sharp & Dohme). Study of metabolites: Z. H. Israili et al., J. Med. Chem. 15, 709 (1972). Clinical pharmacokinetics: R. F. Cunningham et al., Clin. Pharmacokinet. 6, 135 (1981). Toxicology studies: S. E. McKinney et al., J. Pharmacol. Exp. Ther. 102, 208 (1951); NTP Technical Report 395 (PB92-129584, 1991) 220 pp. Comprehensive description: A. A. Al-Badr, H. A. El-Obeid, Anal. Profiles Drug Subs. 10, 639-663 (1981).
Properties: Crystals from dilute alcohol, mp 194-196°. uv max (0.1N NaOH): 242.5 nm. pKa 5.8. Slightly bitter taste, pleasant aftertaste. Sol in chloroform, in dil solns of NaOH buffered to pH 7.4. Nearly insol in water.
Melting point: mp 194-196°
pKa: pKa 5.8
Absorption maximum: uv max (0.1N NaOH): 242.5 nm
 
Derivative Type: Sodium salt
CAS Registry Number: 23795-03-1
Molecular Formula: C13H18NNaO4S
Molecular Weight: 307.34
Percent Composition: C 50.80%, H 5.90%, N 4.56%, Na 7.48%, O 20.82%, S 10.43%
Properties: LD50 in mice (mg/kg): 458 i.v., 1156 s.c., 1666 orally; in rats (mg/kg): 394 i.p., 611 s.c., 1604 orally (McKinney).
Toxicity data: LD50 in mice (mg/kg): 458 i.v., 1156 s.c., 1666 orally; in rats (mg/kg): 394 i.p., 611 s.c., 1604 orally (McKinney)
 
Therap-Cat: Uricosuric.
Keywords: Antigout; Uricosuric.