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CAS No 57-67-0 , 2-(4-aminophenyl)sulfonylguanidine

  • Name: 2-(4-aminophenyl)sulfonylguanidine
  • Synonyms: Sulfanilylguanidine; Sulfanilguanidine; N1-Amidinosulfanilamide; Sulphaguanidine; Sulfaguine;2-(4-aminophenyl)sulfonylguanidine; Aterian;Sulfaguanidin; Guanicil;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 190-193 ºC
  • Flash Point: 249.2°C
  • Boiling Point: 488.4°Cat760mmHg
  • Density: 1.62g/cm3
  • Refractive index: 1.695
  • Water Solubility: 1G/1000ML AT 25 ºC
  • Safety Statements: S26S36
  • Hazard Symbols: UN NO.
  • Flash Point: 249.2°C
  • EINECS: 200-345-9
  • Molecular Weight: 214.2449
  • InchiKey: BRBKOPJOKNSWSG-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,
    10,11)
  • Risk Statements: 36/37/38
  • Molecular Formula: C7H10N4O2S
  • Molecular Structure:CAS No:57-67-0 2-(4-aminophenyl)sulfonylguanidine

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References of 2-(4-aminophenyl)sulfonylguanidine
Title: Sulfaguanidine
CAS Registry Number: 57-67-0
CAS Name: 4-Amino-N-(aminoiminomethyl)benzenesulfonamide
Synonyms: 4-amino-N-(diaminomethylene)benzenesulfonamide; N1-amidinosulfanilamide; N1-guanylsulfanilamide; p-aminobenzenesulfonylguanidine; sulfanilylguanidine
Manufacturers' Codes: RP-2275
Trademarks: Diacta (Nicholas); Ganidan (Specia); Guanicil (Cilag); Resulfon (Nordmark); Shigatox (Fawns & McAllan)
Molecular Formula: C7H10N4O2S
Molecular Weight: 214.24
Percent Composition: C 39.24%, H 4.70%, N 26.15%, O 14.94%, S 14.97%
Literature References: Prepd by condensing acetylsulfanilyl chloride with guanidine nitrate in the presence of much NaOH in water-acetone: Winnek, US 2218490 (1940); US 2229784 (1941); US 2233569 (1941); or by fusing N4-acetylsulfanilamide and dicyanodiamide: Haworth, Rose, GB 551524 (1943). Additional syntheses: ACS Monograph Series no. 106, entitled "Sulfonamides and Allied Compounds," E. H. Northey, Ed. (Reinhold, New York, 1948). Revised structure: G. R. Sullivan, J. D. Roberts, J. Org. Chem. 42, 1095 (1977). Review of pharmacology: E. K. Marshall, Jr. et al., Bull. Johns Hopkins Hosp. 67, 163-188 (1940); E. Pick, J. Mt. Sinai Hosp. 10, 343-354 (1943).
 
Derivative Type: Monohydrate
Properties: Needles. When anhydr, mp 190-193°. One gram dissolves in about 1000 ml water at 25° and in about 10 ml at 100°. Sparingly sol in alcohol or acetone. Freely sol in dil mineral acids. Insol in NaOH solns at room temp.
Melting point: mp 190-193°
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antimicrobial. In enteric infections.
Keywords: Antibacterial (Synthetic); Sulfonamides.