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CAS No 58-14-0 , 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine

  • Name: 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
  • Synonyms: Ethylpyrimidine; Pirimecidan; Malocide; Khloridin; 58-14-0; Chloridin;Daraprim; Diaminopyritamin; Chloridine;5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 233-234 ºC
  • Flash Point: 251°C
  • Boiling Point: 491.5°Cat760mmHg
  • Density: 1.305g/cm3
  • Refractive index: 1.655
  • Water Solubility: <0.01 G/100 ML AT 21 ºC
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 251°C
  • EINECS: 200-364-2
  • Molecular Weight: 248.71142
  • InchiKey: WKSAUQYGYAYLPV-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-
    6H,2H2,1H3,(H4,14,15,16,17)
  • Risk Statements: R22,
  • Molecular Formula: C12H13ClN4
  • Molecular Structure:CAS No:58-14-0 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine

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References of 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
Title: Pyrimethamine
CAS Registry Number: 58-14-0
CAS Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Synonyms: 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine
Manufacturers' Codes: RP-4753
Trademarks: Daraprim (GSK); Malocide (Aventis)
Molecular Formula: C12H13ClN4
Molecular Weight: 248.71
Percent Composition: C 57.95%, H 5.27%, Cl 14.25%, N 22.53%
Literature References: Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Prepn: P. B. Russell, G. H. Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); G. H. Hitchings et al., US 2576939 (1951 to Burroughs Wellcome); W. Logemann et al., Ber. 87, 435 (1954); R. M. Jacob, US 2680740 (1954 to Rh?ne-Poulenc). Review of antimicrobial activity and mechanism of action: Burchall in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 312-320. Comprehensive description: M. A. Loutfy, H. Y. Aboul-Enein, Anal. Profiles Drug Subs. 12, 463-482 (1983). LC-MS determn in plasma: B. A. Sinnaeve et al., J. Chromatogr. A 1076, 97 (2005). Clinical evaluations in toxoplasmosis in AIDS patients: C. Leport et al., Am. J. Med. 84, 94 (1988); B. Dannemann et al., Ann. Intern. Med. 116, 33 (1992). Review of clinical experience in malaria: H. M. McIntosh et al., Ann. Trop. Med. Parasitol. 93, 265-270 (1998); C. V. Plowe et al., Br. Med. J. 328, 545 (2004).
Properties: Crystals, mp 233-234° (capillary); mp 240-242° (copper block). Practically insol in water. Slightly sol in ethanol, (about 9 g/l), in dil HCl (about 5 g/l); sol in boiling ethanol (about 25 g/l). Very sparingly sol in propylene glycol and dimethylacetamide at 70°.
Melting point: mp 233-234° (capillary); mp 240-242° (copper block)
 
Derivative Type: Combination with sulfadoxine
CAS Registry Number: 37338-39-9
Trademarks: Fansidar (Roche)
 
Therap-Cat: Antiprotozoal (Toxoplasma); antimalarial.
Therap-Cat-Vet: Antiprotozoal (Toxoplasma).
Keywords: Antimalarial; Antiprotozoal (Toxoplasma).