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CAS No 58-25-3 , 7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine

  • Name: 7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine
  • Synonyms: Chloridiazepide; Elenium;Chlozepid; Methaminodiazepoxide; Chlordiazepoxid; Chlorodiazepoxide;7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine; Librelease; Helogaphen;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 236-236.5 deg C
  • Flash Point: 226.6°C
  • Boiling Point: 451°Cat760mmHg
  • Density: 1.29g/cm3
  • Safety Statements: Poison by ingestion, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Human male reproductive effects by ingestion: impotence. Human systemic effects by ingestion: sleep, euphoria, somnolence, ataxia, and antianxiety. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Has been implicated in development of aplastic anemia. Used as a pharmaceutical and veterinary drug. When heated to decomposition it emits very toxic fumes of NOx.
  • Flash Point: 226.6°C
  • EINECS: 200-371-0
  • Molecular Weight: 299.75486
  • InchiKey: BUCORZSTKDOEKQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-
    8-14(13)19-15/h2-9,21H,10H2,1H3
  • Molecular Formula: C16H14ClN3O
  • Molecular Structure:CAS No:58-25-3 7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine
References of 7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine
Title: Chlordiazepoxide
CAS Registry Number: 58-25-3
CAS Name: 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
Synonyms: 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide; methaminodiazepoxide; clopoxide
Trademarks: Helogaphen (Spitzner); Libritabs (Roche); Multum (Chephasaar); Risolid (Dumex); Silibrin (Silesia); Tropium (DDSA)
Molecular Formula: C16H14ClN3O
Molecular Weight: 299.75
Percent Composition: C 64.11%, H 4.71%, Cl 11.83%, N 14.02%, O 5.34%
Literature References: Prototype of the benzodiazepine anxiolytics. Prepn: Sternbach, US 2893992 (1959 to Hoffmann-La Roche); Sternbach, Reeder, J. Org. Chem. 26, 1111 (1961). Comprehensive description: A. MacDonald et al., Anal. Profiles Drug Subs. 1, 15-51 (1972). Review of pharmacokinetics: D. J. Greenblatt et al., Clin. Pharmacokinet. 3, 381-394 (1978); of pharmacology and effect on cognitive function: J. B. Murray, Genet. Psychol. Monogr. 109 (2), 167-197 (1984). Clinical trial in alcohol withdrawal: A. K. Burroughs et al., Alcohol Alcohol. 20, 263 (1985).
Properties: Light yellow plates from ethanol, mp 236-236.5°. pK 4.8.
Melting point: mp 236-236.5°
pKa: pK 4.8
 
Derivative Type: Hydrochloride
CAS Registry Number: 438-41-5
Trademarks: Ansiacal (Beolet); A-Poxide (Abbott); Balance (Yamanouchi); Benzodiapin (Lisapharma); Cebrum (SIFA); Corax (Empire); Disarim (Bial); Elenium (Polfa); Equibral (Ravizza); Labican (Boniscontro); Lentotran (Farmopatria); Librium (Roche); O.C.M. (Gobbi-Novag); Psichial (Lang); Psicoterina (Francia); Reliberan (Geymonat); Seren Vita (Synthelabo); SK-Lygen (SKB); Viansin (Farmocosmici)
Molecular Formula: C16H14ClN3O.HCl
Molecular Weight: 336.22
Percent Composition: C 57.16%, H 4.50%, Cl 21.09%, N 12.50%, O 4.76%
Properties: Crystals from methanol, mp 213°. Sol in water.
Melting point: mp 213°
 
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Therap-Cat-Vet: Tranquilizer.
Keywords: Anxiolytic; Benzodiazepine Derivatives.