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CAS No 58-85-5 , D-Biotin

  • Name: D-Biotin
  • Synonyms: Biotin; Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid;D-Biotin; D-Biotin pure; Vitamin B7;Vitamin H; Vitamin H (D-Biotin);
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 231-233 ºC
  • Density: 1.267 g/cm3
  • Refractive index: 90.5 ° (C=2, 0.1mol/L NaOH)
  • Alpha: 89 º (C=1, 0.1N NAOH)
  • Safety Statements: S24/25
  • Hazard Symbols: Xn
  • HS Code: 29362930
  • EINECS: 200-399-3
  • Molecular Weight: 244.31
  • InChI: InChI=1/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)
  • Risk Statements: S24/25
  • Molecular Formula: C10H16N2O3S
  • Molecular Structure:CAS No:58-85-5 D-Biotin
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58-85-5 Vitamin H

  • China Shanghai GL Peptide Ltd [Manufacturers]
  • Tel: 86-21-61263381
  • Fax: 86-21-61263399
  • Address: 519 Ziyue Road, Minhang, Shanghai, China Shanghai,ShanghaiChina
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58-85-5 D-BIOTIN

  • United States AMRESCO Inc. [Manufacturer]
  • Tel: 440-349-1313
  • Fax: 440-349-1182
  • Address: AMRESCO Inc.
    30175 Solon Industrial Parkway
    Solon, OH 44139 ,United States
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58-85-5 D-Biotin

  • D-Biotin
  • China GL Biochem (Shanghai) Ltd. [Distributor/Wholesaler]
  • Tel: +86-(21)-61263306
  • Fax: +86-(21)-61263300
  • Address: 519 Zi Yue Road, Shanghai, China 200241, ShangHai,ShangHaiChina
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58-85-5 Vitamin H

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58-85-5 D-BIOTIN FOR BIOCHEMISTRY (VITAMIN H)

  • D-BIOTIN FOR BIOCHEMISTRY (VITAMIN H)
  • India Alpha Chemika [Manufacturer]
  • Tel: +91-22-22061123
  • Fax: +91-22-22061123
  • Address: 240,Dr.C.H.SREET,Dhobi talav.,behind parsi Dairy , Marine lines(E),MUMBAI-400 002. INDIA INDIA ,India
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58-85-5 D-BIOTIN FOR BIOCHEMISTRY (VITAMIN H)

  • D-BIOTIN FOR BIOCHEMISTRY (VITAMIN H)
  • India alpha chemika [Manufacturer]
  • Tel: 91-22-22061123 / 56382501 / 56218147
  • Fax: 91-22-22061123
  • Address: 240,Dr.C.H.SREET,Dhobi talav.,behind parsi Dairy , Marine lines(E) 400 002 MUMBAIINDIA 400 002 MUMBAI,India
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58-85-5 Vitamin H

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58-85-5 Vitamin H

  • China A & Z Food Additives.Co.,Ltd [Importer/Exporter]
  • Tel: 0086 571 85126931
  • Fax: 0086 571 85126959
  • Address: gucui road Hang zhou,Zhe JiangChina
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58-85-5 D-biotin

  • D-biotin, 99%
  • China trademaxchem [Manufacturer]
  • Tel: 0086 21 52387770 x 1009
  • Fax: 0086 21 52387129
  • Address: 728 Yan-an Road (West), Huamin Empire Plaza, Suite 7B, Shanghai 200050, China. 200050 ShanghaiCHINA Shanghai,China
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58-85-5 D-(+)-BIOTIN

  • Germany Beckmann-Kenko GmbH [Manufacturer]
  • Tel: +49 4241 9308-88
  • Fax: +49 4241 9308-89
  • Address: Beckmann-Kenko GmbH
    AUF DEM SCHEUNENBRINK 8
    D-27211 BASSUM, GERMANY ,Germany
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References of D-Biotin
Title: Biotin
CAS Registry Number: 58-85-5
CAS Name: Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid
Synonyms: cis-tetrahydro-2-oxothieno[3,4-d]imidazoline-4-valeric acid; cis-hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid; vitamin H; coenzyme R; bios II
Trademarks: Biodermatin (Lafare)
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.31
Percent Composition: C 49.16%, H 6.60%, N 11.47%, O 19.65%, S 13.12%
Literature References: Growth factor present in minute amounts in every living cell. Plays an indispensable role in numerous naturally occurring carboxylation reactions. Occurs mainly bound to proteins or polypeptides. The richest sources are liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tumors is higher than that of normal tissue. Biotin combines with the proteinaceous substance, avidin, in raw egg-white and becomes inactive. When on diets contg large amounts of raw egg-white the rat or chick develops characteristic skin lesions and growth is retarded; these symptoms can be prevented by feeding additional biotin. Isoln from egg yolk: K?gl, T?nnis, Z. Physiol. Chem. 242, 43 (1936); from liver: Gy?rgy et al., J. Biol. Chem. 131, 745 (1939); du Vigneaud et al., ibid. 140, 643 (1941). Identity of biotin with vitamin H: du Vigneaud et al., Science 92, 62 (1940). Structure: du Vigneaud et al., J. Biol. Chem. 146, 475 (1942). First synthesis: Harris et al., J. Am. Chem. Soc. 67, 2096 (1945). Configuration: Traub, Nature 178, 649 (1956). Stereospecific total synthesis of the naturally occurring d-form: P. N. Confalone et al., J. Am. Chem. Soc. 97, 5936 (1975); eidem, J. Org. Chem. 42, 1630 (1977); T. Ogawa et al., Carbohydr. Res. 57, C31 (1977); F. G. M. Vogel et al., Ann. 1980, 1972; R. R. Schmidt, M. Maier, Synthesis 1982, 747. Synthesis of the dl-form: P. N. Confalone et al., Helv. Chim. Acta 59, 1005 (1976); M. Marx et al., J. Am. Chem. Soc. 99, 6794 (1977); A. Fliri, K. Hohenlohe-Oehringen, Ber. 113, 607 (1980); Ph. Rossy et al., Tetrahedron Lett. 22, 3493 (1981). Biosynthetic studies: R. J. Parry, M. G. Kunitani, J. Am. Chem. Soc. 98, 4024 (1976); R. J. Parry, M. V. Naidu, Tetrahedron Lett. 1980, 4783. Coordination properties: H. Siegel, Experientia 37, 789 (1981). Mechanism of action: M. J. Cravey, H. Kohn, J. Am. Chem. Soc. 102, 3928 (1980); D. L. Vesely, Science 216, 1329 (1982). Reviews: A. F. Wagner, K. Folkers, Vitamins and Coenzymes (Wiley, New York, 1964) pp 138-159; Harris in The Vitamins vol. II, W. H. Sebrell, R. S. Harris, Eds. (Academic Press, New York, 2nd ed., 1968) pp 261-359; D. B. McCormick, Nutr. Rev. 33, 97-102 (1975). Review of assay methods: P. Gy?rgy, The Vitamins vol. VII, P. Gyorgy, W. N. Pearson, Eds. (1967) pp 303-313.
Properties: Characteristics of biotin isolated from liver or milk (K?gl's b-biotin): fine long needles, mp 232-233°. [a]D21 +91° (c = 1 in 0.1N NaOH). Isoelec pt pH 3.5. pH of 0.01% aq soln 4.5. Soly at 25° (mg/100 ml): water ~22; 95% alc ~80. More sol in hot water and in dil alkali. Insol in other common organic solvents. The pure compd is stable to air and temp. Moderately acid and neutral solns are stable several months; alkaline solns are less stable, but appear reasonably stable up to a pH of about 9. Aq solns are very susceptible to mold growth. Acidic solns can be heat sterilized.
Melting point: mp 232-233°
Optical Rotation: [a]D21 +91° (c = 1 in 0.1N NaOH)
Therap-Cat: Vitamin (enzyme cofactor).
Therap-Cat-Vet: Vitamin (enzyme cofactor).
Keywords: Vitamin/Vitamin Source.