Home > Name List By other > (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino] pentanedioic acid

CAS No 59-30-3 , (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]
pentanedioic acid

  • Name: (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]
    pentanedioic acid
  • Synonyms: Pteroylglutamic acid; Vitamin M;(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]
    pentanedioic acid; Folacin; Acifolic;Folate; Folicet; Folvite; Incafolic; Vitamin Bc;
  • CAS Registry Number:
  • Melting Point: 250 ºC
  • Density: 1.68 g/cm3
  • Alpha: 20 º (C=1, 0.1N NAOH)
  • Water Solubility: 1.6 MG/L (25 ºC)
  • Safety Statements: S24/25
  • Hazard Symbols: Xn
  • EINECS: 200-419-0
  • Molecular Weight: 441.39746
  • InchiKey: OVBPIULPVIDEAO-LBPRGKRZSA-N
  • InChI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-
    1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,
    29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
  • Risk Statements: S24/25
  • Molecular Formula: C19H19N7O6
  • Molecular Structure:CAS No:59-30-3 (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]<br />pentanedioic acid
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59-30-3 Folic Acid

  • Folic Acid, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,China
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59-30-3 FOLIC ACID FOR ANALYTICAL PURPOSE

  • FOLIC ACID FOR ANALYTICAL PURPOSE
  • United States INTERNATIONAL LABORATORY LIMITED [Manufacturer]
  • Tel: ( 650 ) 278-9963
  • Fax: ( 650 ) 589-2786
  • Address: 1067 SNEATH LN SAN BRUNO CA 94066, USA SAN BRUNOUNITED STATES SAN BRUNO,United States
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59-30-3 Pteroyglutamic acid

  • Pteroyglutamic acid
  • United States RIA International [Manufacturer]
  • Tel: 19735811282
  • Fax: 19735811283
  • Address: 11 Melanie Lane #17 East Hanover 07936 NJ UNITED STATES NJ,United States
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59-30-3 Pteroylglutamic acid

  • Pteroylglutamic acid, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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59-30-3 Folic Acid

  • Folic Acid, 99%UP
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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59-30-3 FOLIC ACID(VITAMIN M)(BASF)(SH)

  • FOLIC ACID(VITAMIN M)(BASF)(SH)Pteroylglutamic acid
  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 ,United States
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59-30-3 folic acid

  • folic acid
  • Germany Paragos [Manufacturer]
  • Tel: +49 69 41 09 21 91
  • Fax: +49 69 42 69 45 85
  • Address: Alt Fechenheim 3460386 Frankfurt/MainGERMANY Frankfurt/Main,Germany
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59-30-3 Folic Acid

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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59-30-3 Folic acid

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59-30-3 Folic Acid

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References of (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]
pentanedioic acid
Title: Folic Acid
CAS Registry Number: 59-30-3
CAS Name: N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
Synonyms: N-[p-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic acid; pteroylglutamic acid; N-(p-[(2-amino-4-hydroxypyrimido[4,5-b]pyrazin-6-yl)methylamino]benzoyl)glutamic acid; PGA; liver Lactobacillus casei factor; vitamin Bc; vitamin M; fols?ure
Trademarks: Folacin; Foldine (Specia); Foliamin; Folicet (Mission Pharmacal); Folipac; Folettes (Fawns & McAllan); Folsan (Kali-Chemie); Folvite (Lederle); Incafolic; Millafol (Parke-Davis)
Molecular Formula: C19H19N7O6
Molecular Weight: 441.40
Percent Composition: C 51.70%, H 4.34%, N 22.21%, O 21.75%
Literature References: Hematopoietic vitamin present, free or combined with one or more additional molecules of L(+)-glutamic acid, in liver, kidney, mushrooms, spinach, yeast, green leaves, grasses: Mitchell et al., J. Am. Chem. Soc. 63, 2284 (1941). Isoln: Pfiffner et al., ibid. 69, 1476 (1947); Stokstad et al., ibid. 70, 3 (1948). Structure: Mowat et al., ibid. 14. Crystal structure: D. Mastropaolo et al., Science 210, 334 (1980). History of the different folic acid factors: Ann. N.Y. Acad. Sci. 48, 255-350 (1946). See also reviews by Subbarow et al. in Vitam. Horm. 3, 237-296 (1945); Pfiffner, Hogan, ibid. 4, 1-13 (1946). Several syntheses, see reviews by Gates, Chem. Rev. 41, 63-95 (1947); Hutchings, Mowat, Vitam. Horm. 6, 1-25 (1948); Sletzinger et al., J. Am. Chem. Soc. 77, 6365 (1955); US 2786056; US 2816109; US 2821527; US 2821528 (all 1958 to Merck & Co.); Sadao Kawanishi, US 2956057 (1960 to Kongo Kagaku Kabushiki Kaisha). Alternate syntheses: Bieri, Viscontini, Helv. Chim. Acta 56, 2905 (1973); E. Khalifa et al., ibid. 59, 242 (1976). Comprehensive reviews: Jaenicki, Kutzbach, Fortschr. Chem. Org. Naturst. 21, 183-274 (1963); Marchetti, Acta Vitaminol. Enzymol. 25, 41-64 (1971); F. J. Al-Shammary et al., Anal. Profiles Drug Subs. 19, 221-259 (1990). Review of role in prevention of neural tube defects: G. J. Locksmith, P. Duff, Obstet. Gynecol. 91, 1027-1034 (1998).
Properties: Yellowish-orange crystals. Extremely thin platelets (elongated at two ends) from hot water, no mp. Darkens and chars from about 250°. [a]D25 +23° (c = 0.5 in 0.1N NaOH). uv max (pH 13): 256, 283, 368 nm (log e 4.43, 4.40, 3.96). Very slightly sol in cold water (0.0016 mg/ml at 25°), sol to about 1% in boiling water. Slightly sol in methanol, appreciably less sol in ethanol and butanol. Insol in acetone, chloroform, ether, benzene. Relatively sol in acetic acid, phenol, pyridine, solns of alkali hydroxides and carbonates. Sol in hot dil HCl and H2SO4. Injectable solns are prepd by dissolving folic acid in normal sodium bicarbonate soln (which should be sterilized by filtration) or by preparing solns of the sodium or methylglucamine salt. A suspension of 1 g folic acid in 10 ml water has a pH of 4.0-4.8. Aq solns prepd with sodium bicarbonate have a pH between 6.5 and 6.8.
Optical Rotation: [a]D25 +23° (c = 0.5 in 0.1N NaOH)
Absorption maximum: uv max (pH 13): 256, 283, 368 nm (log e 4.43, 4.40, 3.96)
Therap-Cat: Vitamin (hematopoietic).
Therap-Cat-Vet: Nutritional factor (dietary requirement in poultry).
Keywords: Vitamin/Vitamin Source.