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CAS No 59-42-7 , 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol

  • Name: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
  • Synonyms: L-Phenylephrine; Mezaton; Mesaton; Metasympatol;3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol; Metaoxedrinum; m-Oxedrine; m-Sympatol;Neosynephrine; Visadron;
  • CAS Registry Number:
  • Melting Point: 171°C
  • Flash Point: 163.4ºC
  • Boiling Point: 341.1ºC at 760 mmHg
  • Density: 1.159 g/cm3
  • Refractive index: -55.5 ° (C=5, 1mol/L HCl)
  • Safety Statements: 26-36-45
  • Flash Point: 163.4ºC
  • EINECS: 200-424-8
  • Molecular Weight: 167.20502
  • InchiKey: SONNWYBIRXJNDC-VIFPVBQESA-N
  • InChI: InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,
    1H3/t9-/m0/s1
  • Risk Statements: 22-36/37/38
  • Molecular Formula: C9H13NO2
  • Molecular Structure:CAS No:59-42-7 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol

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References of 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
Title: Phenylephrine
CAS Registry Number: 59-42-7
CAS Name: (aR)-3-Hydroxy-a-[(methylamino)methyl]benzenemethanol
Synonyms: (-)-m-hydroxy-a-[(methylamino)methyl]benzyl alcohol; l-1-(m-hydroxyphenyl)-2-methylaminoethanol; l-a-hydroxy-b-methylamino-3-hydroxy-1-ethylbenzene; m-methylaminoethanolphenol; metaoxedrin
Molecular Formula: C9H13NO2
Molecular Weight: 167.21
Percent Composition: C 64.65%, H 7.84%, N 8.38%, O 19.14%
Literature References: a-Adrenergic agonist. Prepn: H. Legerlotz, US 1932347 (1933 to Frederick Stearns); E. D. Bergmann, M. Sulzbacher, J. Org. Chem. 16, 84 (1951); M. K. Gurjar et al., Org. Process Res. Dev. 2, 422 (1998). Spectrophotometric determn: S. A. Shama, J. Pharm. Biomed. Anal. 30, 1385 (2002). Toxicity data: M. R. Warren, H. W. Werner, J. Pharmacol. Exp. Ther. 86, 284 (1946). Clinical efficacy in mydriasis: V. Tanner, A. G. Casswell, Eye 10, 95 (1996). Clinical evaluation in fecal incontinence: M. J. Cheetham et al., Gut 48, 356 (2001). Comprehensive description: C. A. Gaglia, Jr., Anal. Profiles Drug Subs. 3, 483-512 (1974). Review of ophthalmologic uses: S. M. Meyer, F. T. Fraunfelder, Ophthalmology 87, 1177-1180 (1980); of clinical trials vs ephedrine, q.v., in treatment of hypotension during cesarean delivery: A. Lee et al., Anesth. Analg. 94, 920-926 (2002).
Properties: mp 170-171°.
Melting point: mp 170-171°
 
Derivative Type: Hydrochloride
CAS Registry Number: 61-76-7
Trademarks: Ak-Dilate (Akorn); Ak-Nefrin (Akorn); Alconefrin (Polymedica); Incostop (SLA Pharma); Mydfrin (Alcon); Neo-Synephrine (Bayer); Nostril (Novartis); Prefrin (Allergan); Rhinall (Scherer)
Molecular Formula: C9H13NO2.HCl
Molecular Weight: 203.67
Percent Composition: C 53.07%, H 6.93%, N 6.88%, O 15.71%, Cl 17.41%
Properties: Bitter crystals, mp 140-145°. [a]D -44.0° (c = 2.16 in H2O). pK1 8.77; pK2 9.84. uv max (0.05 N HCl): 216, 274, 279 nm (e ′ 10-3 5.91, 1.81, 1.65). uv max (0.05 N NaOH): 239, 292.5 (e ′ 10-3 8.95, 3.04). Freely sol in water or alcohol. LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner).
Melting point: mp 140-145°
pKa: pK1 8.77; pK2 9.84
Optical Rotation: [a]D -44.0° (c = 2.16 in H2O)
Absorption maximum: uv max (0.05 N HCl): 216, 274, 279 nm (e ′ 10-3 5.91, 1.81, 1.65); uv max (0.05 N NaOH): 239, 292.5 (e ′ 10-3 8.95, 3.04)
Toxicity data: LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner)
 
Therap-Cat: Mydriatic; decongestant; in treatment of fecal incontinence.
Keywords: a-Adrenergic Agonist; Decongestant; Mydriatic.