Home > Name List By p > Prost-13-en-1-oic acid,11,16-dihydroxy-16-methyl-9-oxo-, methyl ester, (11a,13E)-(?à)- Canada

CAS No 59122-46-2 , Prost-13-en-1-oic acid,11,16-dihydroxy-16-methyl-9-oxo-, methyl ester, (11a,13E)-(?à)- Search by region : Canada

  • CAS Registry Number:
  • Transport: UN 2810
  • Density: 1.078 g/cm3
  • Water Solubility: Soluble to 100 mM in Ethanol
  • Safety Statements: Poison by ingestion, intramuscular, and intraperitoneal routes. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 382.60
  • InChI: InChI=1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18-,20-,22?/m1/s1
  • Risk Statements: R60;R61;R25
  • Molecular Formula: C22H38 O5
  • Molecular Structure:CAS No:59122-46-2 Prost-13-en-1-oic acid,11,16-dihydroxy-16-methyl-9-oxo-, methyl ester, (11a,13E)-(?à)-

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59122-46-2 Prost-13-en-1-oic acid,11,16-dihydroxy-16-methyl-9-oxo-, methyl ester, (11a,13E)-(?à)-

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59122-46-2 MISOPROSTOL

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References of Prost-13-en-1-oic acid,11,16-dihydroxy-16-methyl-9-oxo-, methyl ester, (11a,13E)-(?à)-
Title: Misoprostol
CAS Registry Number: 59122-46-2
CAS Name: (11a,13E)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester
Synonyms: (±)-methyl-(1R,2R,3R)-3-hydroxy-2-[(E)-(4RS)-4-hydroxy-4-methyl-1-octenyl]-5-oxocyclopentaneheptanoate; (±)-15-deoxy-(16RS)-16-hydroxy-16-methyl-PGE1 methyl ester
Manufacturers' Codes: SC-29333
Trademarks: Cytotec (Pfizer)
Molecular Formula: C22H38O5
Molecular Weight: 382.53
Percent Composition: C 69.08%, H 10.01%, O 20.91%
Literature References: Cytoprotective prostaglandin PGE1 analog; also exhibits uterotonic and cervical-ripening actions. Double racemate comprised of the (+)- and (-)-enantiomers of the 16R- and 16S-forms. The pharmacologically active form is the (11R,16S)-enantiomer. Prepn: P. W. Collins, R. Pappo, BE 827127; eidem, US 3965143 (1975, 1976 both to Searle); P. W. Collins et al., Tetrahedron Lett. 48, 4217 (1975). Prepn, activity, NMR data: P. Collins et al., J. Med. Chem. 20, 1152 (1977). HPLC resolution of enantiomers: D. A. Roston, R. Wijayaratne, Anal. Chem. 60, 948 (1988). Mechanism of gastric secretory inhibition: D. G. Colton et al., Arch. Int. Pharmacodyn. Ther. 236, 86 (1978). Symposium on pharmacology and clinical efficacy: Dig. Dis. Sci. 30, Suppl. 11, 114S-205S (1985). Toxicity data: F. N. Kotsonis et al., ibid. 142S. Clinical trial in prevention of NSAID-induced ulcer: D. Y. Graham et al., Ann. Intern. Med. 119, 257 (1993); to induce labor: H. Fletcher et al., Obstet. Gynecol. 83, 244 (1994). Review of clinical experience in pregnancy: A. B. Goldberg et al., N. Engl. J. Med. 344, 38-47 (2001).
Properties: Light yellow oil. Sol in water. LD50 in rats, mice (mg/kg): 40-62, 70-160 i.p.; 81-100, 27-138 orally (Kotsonis).
Toxicity data: LD50 in rats, mice (mg/kg): 40-62, 70-160 i.p.; 81-100, 27-138 orally (Kotsonis)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Prostaglandin/Prostaglandin Analog.