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CAS No 60-18-4 , (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid

  • Name: (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
  • Synonyms: 60-18-4; Tyrosine; 4-Hydroxy-L-phenylalanine; (S)-Tyrosine; L-; L-(-)-Tyrosine; p-Tyrosine; L-p-Tyrosine;(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid; tyrosine;L-tyrosine;
  • CAS Registry Number:
  • Melting Point: 290 ºC
  • Flash Point: 176 ºC
  • Density: 1.34
  • Refractive index: -12 ° (C=5, 1mol/L HCl)
  • Alpha: -11.65 º (C=5,DIL HCL/H2O 50/50)
  • Water Solubility: 0.45 G/L (25 ºC)
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 176 ºC
  • EINECS: 200-460-4
  • Molecular Weight: 181.18854
  • InchiKey: OUYCCCASQSFEME-QMMMGPOBSA-N
  • InChI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,
    12,13)/t8-/m0/s1
  • Risk Statements: S26;S36
  • Molecular Formula: C9H11NO3
  • Molecular Structure:CAS No:60-18-4 (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
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60-18-4 L-TYROSINE

  • United States Advanced Synthesis Technologies [Manufacturer]
  • Tel: 619-423-7821
  • Fax: 619-423-7793
  • Address: Advanced Synthesis
    P.O. Box 437920
    San Ysidro, CA 92173 null,nullUnited States
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60-18-4 08088 H-TYR-OH L-TYROSINE

  • Switzerland Senn Chemicals AG [Manufacturer]
  • Tel: +41 (0)43 422 2400
  • Fax: +41 (0)43 422 2424
  • Address: Senn Chemicals AG
    P.O. Box 267
    Guido Senn Strasse 1, CH-8157 Dielsdorf
    Switzerland null,nullSwitzerland
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60-18-4 L-TYROSINE

  • China YANGZHOU CHEMICAL CO.,LTD. [Manufacturers]
  • Tel: 86-514-87864167
  • Fax: +86-514-87859301,87859302,87859303
  • Address: 7/F,18 WEST WENCHANG ROAD,YANGZHOU,JIANGSU,CHINA yangzhou,jiangsuChina
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60-18-4 L-TYROSINE

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60-18-4 L-Tyrosine

  • Switzerland Senn Chemicals AG [Other]
  • Tel: +41-(43)-422-2400
  • Fax: +41-(43)-422-2424
  • Address: Industriestrasse 12, Dielsdorf CH-8157, Dielsdorf,nullSwitzerland
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60-18-4 L-Tyrosine

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60-18-4 L-Tyrosine

  • China TRITON CHEMTECH CO., LTD. null
  • Fax: +86-21-58895894
  • Address: Room 717, 7/F, Information Tower, 1403 Minsheng Road, Shanghai, 200135, China null,nullChina
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60-18-4 L-Tyrosine Granular

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60-18-4 L-Tyrosine

  • China Major Chemicals Co.,Ltd. null
  • Fax: +86-571-88383679
  • Address: Rm.3A05,Sunshine International Commercial Center,No.186-1,Hushu South Road,Hangzhou,the P.R.of China null,nullChina
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60-18-4 L-TYROSINE

  • China Shanghai Lang Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-21-51289991
  • Fax: +86-21-51289992
  • Address: 901 RM,No.970, Dalian RD,
    Hongkou District , Shanghai, China null,nullChina
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References of (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
Title: Tyrosine
CAS Registry Number: 60-18-4
CAS Name: L-Tyrosine
Synonyms: Tyr; Y; b-(p-hydroxyphenyl)alanine; a-amino-p-hydroxyhydrocinnamic acid; (S)-a-amino-4-hydroxybenzenepropanoic acid
Molecular Formula: C9H11NO3
Molecular Weight: 181.19
Percent Composition: C 59.66%, H 6.12%, N 7.73%, O 26.49%
Literature References: Non-essential amino acid for human development; precursor for the synthesis of thyroid hormones and select neurotransmitters, such as dopamine and norepinephrine. May be considered essential by the brain. Name derived from the Greek "tyros" for "cheese" from which it was first identified and isolated: J. Liebig, Ann. 57, 127 (1846); idem, ibid. 62, 257 (1847). Early chemistry and biochemistry: Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) 950 pp., passim; J. P. Greenstein, M. Winitz, Chemistry of the Amino Acids vol 1-3 (John Wiley and Sons, Inc., New York, 1961) pp. 2348-2367, passim. Synthesis of labeled form: Y. Watanabe et al., Acta Radiol. 376 (Suppl.), 110 (1991). Intrinsic fluorophore in proteins; used in characterizing structure and conformational changes: V. Giancotti et al., Biochim. Biophys. Acta 624, 60 (1980); S. T. Ferreira et al., Biophys. J. 66, 1185 (1994); B. Kierdaszuk et al., Photochem. Photobiol. 61, 319 (1995). Review of determn in blood: E. Robins, Methods Biochem. Anal. 17, 287-309 (1969). Review of neurotransmitter synthesis: C. J. Gibson, Retina 2, 332-340 (1982). Review of toxicity: C. Laberge et al., Adv. Exp. Med. Biol. 206, 209-221 (1986). Review of post-translational phosphorylation: S. Atherton-Fessler et al., Semin. Cell Biol. 4, 433-442 (1993); sulfation: C. Niehrs et al., Chem. Biol. Interact. 92, 257-271 (1994).
Properties: Fine silky needles, dec 342-344° (closed capillary, bath preheated to 280°, rapid heating). d 1.456. pK1 2.20; pK2 9.11; pK3 10.07. [a]D22 -10.6° (c = 4 in HCl); [a]D18 -13.2° (c = 4 in 3N NaOH). Soly in water (g/100 g): 0.02 at 0°; 0.045 at 25°; 0.105 at 50°; 0.244 at 75°; 0.565 at 100°. Insol in common neutral solvents, such as abs alcohol, ether, acetone, except water. Sol in alkaline solns.
pKa: pK1 2.20; pK2 9.11; pK3 10.07
Optical Rotation: [a]D22 -10.6° (c = 4 in HCl); [a]D18 -13.2° (c = 4 in 3N NaOH)
Density: d 1.456
 
Derivative Type: DL-Form
Properties: Synthetic product. Stout needles. Dec 316°. Soly in water (g/100 g): 0.0147 at 0°; 0.351 at 25°; 0.0836 at 50°.
 
Derivative Type: D-Form
Properties: Crystals. Dec 310-314°. [a]D25 +10.3° (c = 4 in HCl). Soly in water (g/100 g): 0.196 at 0°; 0.1052 at 50°.
Optical Rotation: [a]D25 +10.3° (c = 4 in HCl)
 
Use: Probe for studying protein structure and dynamics.