CAS No 603-50-9 , [4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate

Title: Bisacodyl
CAS Registry Number: 603-50-9
CAS Name: 4,4￠-(2-Pyridylmethylene)bisphenol diacetate
Synonyms: bis(p-acetoxyphenyl)-2-pyridylmethane; (4,4￠-diacetoxydiphenyl)(2-pyridyl)methane; 2-(4,4￠-diacetoxydiphenylmethyl)pyridine
Trademarks: Contalax (3M Pharma); Correctol (Schering-Plough); Dulcolan (Boehringer, Ing.); Dulcolax (Boehringer, Ing.); Durolax (Boehringer, Ing.); Ex-Lax Ultra (Novartis); Gentlax (Purdue Frederick); Laxadin (Teva); Perilax (Ferring); Pyrilax (Berlin-Chemie); Stadalax (Stada)
Molecular Formula: C22H19NO4
Molecular Weight: 361.39
Percent Composition: C 73.12%, H 5.30%, N 3.88%, O 17.71%
Literature References: Prepn: GB 730243; A. Kottler, E. Seeger, US 2764590 (l955, 1956 both to Thomae). Pharmacology and toxicology: Schmidt, Arzneim.-Forsch. 3, 19 (1953). Comparison of efficacy and safety with other stimulant laxatives: A. Wald, J. Clin. Gastroenterol. 36, 386 (2003).
Properties: Tasteless crystals, mp 138°. Practically insol in water and alkaline solns. Sol in acids, alc, acetone, propylene glycol, and other organic solvents. LD50 orally in rats: >3 g/kg (Schmidt).
Melting point: mp 138°
Toxicity data: LD50 orally in rats: >3 g/kg (Schmidt)
 
Derivative Type: Complex with tannin
CAS Registry Number: 1336-29-4
Synonyms: Bisacodyl tannex
Trademarks: Clysodrast (Barnes-Hind)
 
Therap-Cat: Cathartic.
Keywords: Laxative/Cathartic.