Home > Name List By 7 > 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

CAS No 604-75-1 , 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

  • Name: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
  • Synonyms: Serax; Nesontil; Anxiolit; Psiquiwas; Droxacepam; Ansioxacepam;Adumbran;7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one; Praxiten; Tazepam;
  • CAS Registry Number:
  • Transport: UN 1230 3/PG 2
  • Melting Point: 205-206 deg C
  • Flash Point: 11 °C
  • Boiling Point: 506.5°C at 760 mmHg
  • Density: 1.42g/cm3
  • Refractive index: 1.681
  • Safety Statements: Moderately toxic by intraperitoneal route. Human (child) systemic effects by ingestion: somnolence, changes in REM sleep, and loss of muscle control (ataxia). Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Used to treat anxiety and tension. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also DIAZEPAM.
  • Hazard Symbols: Xn,T,F
  • Flash Point: 11 °C
  • EINECS: 210-076-9
  • Molecular Weight: 286.71304
  • InchiKey: ADIMAYPTOBDMTL-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14
    (19)17-12/h1-8,15,20H,(H,17,19)
  • Risk Statements: 40-39/23/24/25-23/24/25-11
  • Molecular Formula: C15H11ClN2O2
  • Molecular Structure:CAS No:604-75-1 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
References of 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Title: Oxazepam
CAS Registry Number: 604-75-1
CAS Name: 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
Synonyms: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Manufacturers' Codes: Wy-3498
Trademarks: Adumbran (Boehringer, Ing.); Azutranquil (Azupharma); Durazepam (Merck KGaA); Hilong (Wyeth); Limbial (Chiesi); Noctazepam (Hexal); Praxiten (Teofarma); Serax (Wyeth); Serenid (Wyeth); Serepax (Wyeth); Séresta (Biodim); Serpax (Wyeth); Sobril (Pharmacia); Uskan (Desitin)
Molecular Formula: C15H11ClN2O2
Molecular Weight: 286.71
Percent Composition: C 62.84%, H 3.87%, Cl 12.37%, N 9.77%, O 11.16%
Literature References: Prepn: Bell, Childress, J. Org. Chem. 27, 1691 (1962); NL 298071; S. C. Bell, US 3296249 (1965, 1967 both to American Home Prod.). Crystal and molecular structure: G. Gilli et al., Acta Crystallogr. B34, 2826 (1978). Metabolic studies: Sisenwine et al., Arzneim.-Forsch. 22, 682 (1972); Knowles, Ruelius, ibid. 687. Pharmacokinetics: D. J. Greenblatt, Clin. Pharmacokinet. 6, 89 (1981). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: C. M. Shearer, C. R. Pilla, Anal. Profiles Drug Subs. 3, 441-464 (1974). Review: Acta Psychiatr. Scand. Suppl. 274, R. Chinnery, A. Sundwall, Eds. (1978) 128 pp.
Properties: Crystals from alcohol, mp 205-206°. Sol in alcohol, chloroform, dioxane. Practically insol in water. LD50 in mice, rats (mg/kg): >5010, >5010 orally (Goldenthal).
Melting point: mp 205-206°
Toxicity data: LD50 in mice, rats (mg/kg): >5010, >5010 orally (Goldenthal)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.