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CAS No 60569-19-9 , (1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate Search by region : Japan

  • Name: (1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate
  • Synonyms: Propiverinum [INN-Latin]; 60569-19-9; propiverine hydrochloride; 1-Methyl-4-piperidyl diphenylpropoxyacetate; Propiverino [INN-Spanish];(1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate;
  • CAS Registry Number:
  • Density: 1.08 g/cm3
  • Refractive index: 1.57
  • Molecular Weight: 367.48126
  • InchiKey: QPCVHQBVMYCJOM-UHFFFAOYSA-N
  • InChI: InChI=1S/C23H29NO3/c1-3-18-26-23(19-10-6-4-7-11-19,
    20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21/h4-13,21H,3,14-18H2,
    1-2H3
  • Molecular Formula: C23H29NO3
  • Molecular Structure:CAS No:60569-19-9 (1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate

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60569-19-9 Benzeneacetic acid, a-phenyl-a-propoxy-, 1-methyl-4-piperidinylester

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References of (1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate
Title: Propiverine
CAS Registry Number: 60569-19-9
CAS Name: a-Phenyl-a-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester
Synonyms: a,a-diphenyl-a-propoxyacetic acid 1-methyl-4-piperidyl ester; 1-methyl-4-piperidyl diphenylpropoxyacetate
Molecular Formula: C23H29NO3
Molecular Weight: 367.48
Percent Composition: C 75.17%, H 7.95%, N 3.81%, O 13.06%
Literature References: Prepn: C. Starke et al., DD 106643 (1974), C.A. 82, 155841s (1975). GC-MS determn in plasma and urine: T. Marunaka et al., J. Chromatogr. 420, 43 (1987). Pharmacology: A. Haruno, Arzneim.-Forsch. 42, 815, 1459 (1992). Acute toxicity: K. Yamashita et al., J. Toxicol. Sci. 14, Suppl. 2, 1 (1989), C.A. 112, 172060 (1990). Clinical pharmacokinetics: C. Müller et al., Eur. J. Drug Metab. Pharmacokinet. 18, 265 (1993). Clinical trial in urinary incontinence: D. Mazur et al., Urologe A33, 447 (1994).
 
Derivative Type: Hydrochloride
CAS Registry Number: 54556-98-8
Manufacturers' Codes: P-4
Trademarks: Detrunorm (Schering); Mictonorm (Apogepha); Mictonetten (Apogepha)
Molecular Formula: C23H29NO3.HCl
Molecular Weight: 403.94
Percent Composition: C 68.39%, H 7.49%, N 3.47%, O 11.88%, Cl 8.78%
Properties: mp 216-218°. Sparingly sol in water and ethanol. LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita).
Melting point: mp 216-218°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita)
 
Therap-Cat: In treatment of urinary incontinence.
Keywords: Antimuscarinic.