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CAS No 60628-96-8 , 1-[phenyl-(4-phenylphenyl)methyl]imidazole

  • Name: 1-[phenyl-(4-phenylphenyl)methyl]imidazole
  • Synonyms: Trifonazole;1-[phenyl-(4-phenylphenyl)methyl]imidazole;Mycospor; Bifonazol; 60628-96-8; Amycor; Azolmen; Bifonazol [INN-Spanish]; BAY H 4502;
  • CAS Registry Number:
  • Flash Point: 251.2 ºC
  • Boiling Point: 491.7 ºCat 760 mmHg
  • Density: 1.07 g/cm3
  • Refractive index: 1.616
  • Flash Point: 251.2 ºC
  • EINECS: 262-336-6
  • Molecular Weight: 310.39172
  • InchiKey: OCAPBUJLXMYKEJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-
    17-24)20-9-5-2-6-10-20/h1-17,22H
  • Molecular Formula: C22H18N2
  • Molecular Structure:CAS No:60628-96-8 1-[phenyl-(4-phenylphenyl)methyl]imidazole

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References of 1-[phenyl-(4-phenylphenyl)methyl]imidazole
Title: Bifonazole
CAS Registry Number: 60628-96-8
CAS Name: 1-([1,1￠-Biphenyl]-4-ylphenylmethyl)-1H-imidazole
Synonyms: (±)-1-(p,a-diphenylbenzyl)imidazole
Manufacturers' Codes: Bay h 4502
Trademarks: Amycor (Lipha); Azolmen (Menarini); Bedriol (Andromaco); Mycospor (Bayer); Mycosporan (Bayer)
Molecular Formula: C22H18N2
Molecular Weight: 310.39
Percent Composition: C 85.13%, H 5.85%, N 9.03%
Literature References: Antimycotic deriv of imidazole. Prepn: E. Regel et al., DE 2461406; eidem, US 4118487 (1976, 1978 both to Bayer). Series of articles on in vitro and in vivo antimycotic efficacy, microscopic studies, pharmacokinetics, efficacy in dermatomycoses and comparison with clotrimazole and miconazole, q.q.v.: Arzneim.-Forsch. 33, 517-551, 745-754 (1983). Toxicology: G. Schlüter, ibid. 739.
Properties: Crystals from acetonitrile, mp 142°. Very lipophilic. Sol in alcohols, DMF, DMSO. Soly in water at pH 6: <0.1 mg/100 ml. Stable in aq soln at pH 1-12. LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter).
Melting point: mp 142°
Toxicity data: LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter)
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Imidazoles.