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CAS No 62-44-2 , N-(4-ethoxyphenyl)acetamide

  • Name: N-(4-ethoxyphenyl)acetamide
  • Synonyms: N-(4-ethoxyphenyl)acetamide; Contradouleur; Acetophenetidine; p-Acetophenetidide; N-(4-Ethoxyphenyl)acetamide; Acetophenetin; Acetphenetidin;Acetophenetidin;
  • CAS Registry Number:
  • Melting Point: 133-138 ºC
  • Boiling Point: 132 °C / 4mmHg
  • Density: 1.099 g/cm3
  • Refractive index: 1.505 (20 C)
  • Water Solubility: 0.076 G/100 ML
  • Safety Statements: R22;R45
  • Hazard Symbols: T: Toxic;
  • EINECS: 200-533-0
  • Molecular Weight: 179.21572
  • InchiKey: CPJSUEIXXCENMM-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,
    11,12)
  • Risk Statements: S45;S53
  • Molecular Formula: C10H13NO2
  • Molecular Structure:CAS No:62-44-2 N-(4-ethoxyphenyl)acetamide

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References of N-(4-ethoxyphenyl)acetamide
Title: Phenacetin
CAS Registry Number: 62-44-2
CAS Name: N-(4-Ethoxyphenyl)acetamide
Synonyms: p-acetophenetidide; p-ethoxyacetanilide; acetophenetidin; para-acetphenetidin; acet-p-phenetidin; p-acetophenetide
Molecular Formula: C10H13NO2
Molecular Weight: 179.22
Percent Composition: C 67.02%, H 7.31%, N 7.82%, O 17.85%
Literature References: Prepn: Beilstein vol. XIII, 461. Improved process: Eaker, Campbell, US 2887513 (1959 to Monsanto). Monograph: P. K. Smith, Acetophenetidin (Interscience, New York, 1958) 180 pp. Toxicity: Boyd, Toxicol. Appl. Pharmacol. 1, 240 (1959). Review of toxicity and metabolism studies: L. Fishbein, IARC Sci. Publ. 40, 287-310 (1981). Epidemiologic study of renal morbidity and mortality: U. C. Dubach et al., N. Engl. J. Med. 308, 357 (1983). Evaluation of renal effects: D. P. Sandler et al., ibid. 320, 1238 (1989).
Properties: Slightly bitter, cryst scales or powder. mp 134-135°. One gram dissolves in 1310 ml cold water, 82 ml boiling water; 15 ml cold alcohol, 2.8 ml boiling alcohol; 14 ml chloroform, 90 ml ether; sol in glycerol. Gives a pasty mass with phenol, chloral hydrate or pyrocatechol, strong acids or alkalies, salicylic acid, oxidizers, iodine, spirit nitrous ether. LD50 orally in rats: 1.65 g/kg (Boyd).
Melting point: mp 134-135°
Toxicity data: LD50 orally in rats: 1.65 g/kg (Boyd)
NOTE: Component of APC tablets, analgesic mixture also containing aspirin and caffeine.
CAUTION: Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing phenacetin are listed as known human carcinogens: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-212.
Therap-Cat: Analgesic, antipyretic.
Therap-Cat-Vet: Analgesic, antipyretic.
Keywords: Analgesic (Non-Narcotic); Antipyretic.