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CAS No 62013-04-1 , Dirithromycin Search by region : Germany

  • Name: Dirithromycin
  • Synonyms: Dirithromycin;Dirithomycin;[9S(R)]-9-Deoxo-11-deoxy-9,11-[imino[2-(2-methoxy)ethylidene]oxy]erthromycin; 9-(4-Dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-3-ethyl-2,10-dihydroxy-7-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-15-(2-methoxyethoxymethyl)-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one;
  • CAS Registry Number:
  • Melting Point: 185 - 189
  • Density: 1.19 g/cm3
  • Refractive index: 1.533
  • Water Solubility: slightly soluble in water.
  • Safety Statements: R42/43
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 835.07
  • InChI: InChI=1/C42H78N2O14/c1-15-29-42(10,49)37-24(4)32(43-30(56-37)21-52-17-16-50-13)22(2)19-40(8,48)36(58-39-33(45)28(44(11)12)18-23(3)53-39)25(5)34(26(6)38(47)55-29)57-31-20-41(9,51-14)35(46)27(7)54-31/h22-37,39,43,45-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30-,31+,32+,33-,34+,35+,36-,37-,39+,40-,41-,42-/m1/s1
  • Risk Statements: S36
  • Molecular Formula: C42H78N2O14
  • Molecular Structure:CAS No:62013-04-1 Dirithromycin

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62013-04-1 DIRITHROMYCIN

  • Germany Beckmann-Kenko GmbH [Manufacturer]
  • Tel: +49 4241 9308-88
  • Fax: +49 4241 9308-89
  • Address: Beckmann-Kenko GmbH
    AUF DEM SCHEUNENBRINK 8
    D-27211 BASSUM, GERMANY null,nullGermany
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62013-04-1 Dirithromycin

  • Dirithromycin
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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References of Dirithromycin
Title: Dirithromycin
CAS Registry Number: 62013-04-1
CAS Name: (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-7-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-3-ethyl-2,10-dihydroxy-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one
Synonyms: [9S(R)]-9-deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)ethylidene]oxy]erythromycin
Manufacturers' Codes: LY-237216; AS-E 136
Trademarks: Dynabac (Lilly); Noriclan (Lilly); Nortron (Lilly); Valodin (Ferrer)
Molecular Formula: C42H78N2O14
Molecular Weight: 835.07
Percent Composition: C 60.41%, H 9.41%, N 3.35%, O 26.82%
Literature References: Semi-synthetic derivative of erythromycin, q.v. Prepn: BE 840431 (1976 to Thomae); R. Maier et al., US 4048306 (1977 to Boehringer, Ing.). Synthesis, 1H- and 13C-NMR, and antimicrobial evaluation: F. T. Counter et al., Antimicrob. Agents Chemother. 35, 1116 (1991). X-ray structure determn: P. Luger, R. Maier, J. Cryst. Mol. Struct. 9, 329 (1979). HPLC determn in plasma: G. W. Whitaker, T. D. Lindstrom, J. Liq. Chromatogr. 11, 3011 (1988). Symposium on antibacterial activity, pharmacology, and clinical experience: J. Antimicrob. Chemother. 31, Suppl. C, 1-185 (1993).
Properties: Crystals from ethanol/water, mp 186-189° (dec) (Counter). pKa 9.0 in 66% aq dimethyl fluoride. LD50 in mice (g/kg): >1 s.c.; >1 orally (Maier).
Melting point: mp 186-189° (dec) (Counter)
pKa: pKa 9.0 in 66% aq dimethyl fluoride
Toxicity data: LD50 in mice (g/kg): >1 s.c.; >1 orally (Maier)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.