CAS No 63-74-1 , 4-aminobenzenesulfonamide Search by region : Germany

Name: 4-aminobenzenesulfonamide
Synonyms: 4-Aminobenzenesulfonamide; Sulphanilamide; Bacteramid; 63-74-1; Sulfamine;4-aminobenzenesulfonamide; Sulfonylamide; Streptasol; Sulphonamide;
CAS Registry Number:63-74-1
Transport: 25kgs
Melting Point: 164-167 ºC
Flash Point: 196
Boiling Point: 401
Density: 1.08
Refractive index: 1.5897 (158 C)
Water Solubility: 7.5 G/L AT 25 ºC
Safety Statements: S24/25
Hazard Symbols: UN NO.
HS Code: 29350090
Flash Point: 196
EINECS: 200-563-4
Molecular Weight: 172.20492
InchiKey: FDDDEECHVMSUSB-UHFFFAOYSA-N
InChI: InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
Risk Statements: S24/25
Molecular Formula: C₆H₈N₂O₂S
Molecular Structure:

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References of 4-aminobenzenesulfonamide

Title: Sulfanilamide
CAS Registry Number: 63-74-1
CAS Name: 4-Aminobenzenesulfonamide
Synonyms: p-anilinesulfonamide; p-sulfamidoaniline
Manufacturers' Codes: 1162-F
Trademarks: Prontosil album; Prontylin; Streptocide (Frosst)
Molecular Formula: C6H8N2O2S
Molecular Weight: 172.20
Percent Composition: C 41.85%, H 4.68%, N 16.27%, O 18.58%, S 18.62%
Literature References: Active metabolite of the antibacterial dye, sulfamidochrysoidine, q.v. Prepn: P. Gelmo, J. Prakt. Chem. 77, 369 (1908); A. Galat, Ind. Eng. Chem. 36, 192 (1944); Hurdis, Yang, J. Chem. Educ. 46, 697 (1969). Large-scale process: F. Mietzsch, J. Klarer, US 2132178; eidem et al., US 2276664 (1938, 1942 both to Winthrop). Antibacterial activity: J. Tréfouel et al., C.R. Seances Soc. Biol. Ses Fil. 120, 756 (1935); and clinical efficacy: L. Colebrook, A. W. Purdie, Lancet 233, 1291 (1937). Toxicity study: E. K. Marshall, Jr. et al., J. Am. Med. Assoc. 110, 252 (1938). Historical review: M. H. Bickel, Gesnerus 45, 67-86 (1988).
Properties: Crystals from boiling water, mp 164.5-166.5°. Neutral to litmus. pH (0.5% aq soln): 5.8-6.1. uv max: 255, 312 nm. One gram dissolves in about 37 ml alcohol; in about 5 ml acetone; in about 2 ml boiling water. Sol in glycerol, HCl, solns of K and Na hydroxides. Practically insol in chloroform, ether, benzene. LD50 orally in mice: 3.8 g/kg (Marshall).
Melting point: mp 164.5-166.5°
Absorption maximum: uv max: 255, 312 nm
Toxicity data: LD50 orally in mice: 3.8 g/kg (Marshall)

Derivative Type: N4-Acetylsulfanilamide
CAS Registry Number: 121-61-9
CAS Name: N-[4-(Aminosulfonyl)phenyl]acetamide
Molecular Formula: C8H10N2O3S
Molecular Weight: 214.24
Percent Composition: C 44.85%, H 4.70%, N 13.08%, O 22.40%, S 14.97%
Literature References: Major metabolite of sulfanilamide: E. K. Marshall, Jr. et al., Science 85, 202 (1937).
Properties: Needles from water, mp 219°.
Melting point: mp 219°

Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides.