CAS No 636-54-4 , Clopamide Search by region : China

Name: Clopamide
Synonyms: 4-Chloro-N-(cis-2,6-dimethylpiperidino)-3-sulfamoylbenzamide;Clopamide;
CAS Registry Number:636-54-4
Density: 1.39 g/cm3
Refractive index: 1.613
Safety Statements: 36
Hazard Symbols: Xn
EINECS: 211-261-7
Molecular Weight: 345.84
InChI: InChI=1/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+
Risk Statements: 42/43
Molecular Formula: C14H20ClN3O3S
Molecular Structure:

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References of Clopamide

Title: Clopamide
CAS Registry Number: 636-54-4
CAS Name: rel-3-(Aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]benzamide
Synonyms: cis-1-(4-chloro-3-sulfamoylbenzamido)-2,6-dimethylpiperidine; cis-N-(2￠,6￠-dimethyl-1￠-piperidyl)-3-sulfamoyl-4-chlorobenzamide; cis-4-chloro-N-(2￠,6￠-dimethyl-1￠-piperidyl)-3-sulfamoylbenzamide; chlosudimeprimyl
Manufacturers' Codes: DT-327
Trademarks: Adurix (Nycomed); Brinaldix (Novartis)
Molecular Formula: C14H20ClN3O3S
Molecular Weight: 345.84
Percent Composition: C 48.62%, H 5.83%, Cl 10.25%, N 12.15%, O 13.88%, S 9.27%
Literature References: Prepn (stereochemistry unspecified): BE 610039; E. Jucker, A. J. Lindenmann, US 3459756 (1962, 1969 both to Sandoz). Prepn of cis- and trans-forms: eidem, Helv. Chim. Acta 45, 2316 (1962). HPLC determn: R. T. Sane et al., J. Chromatogr. 356, 468 (1986). Pharmacokinetics and diuretic effect in humans: J. J. McNeil et al., Clin. Pharmacol. Ther. 42, 299 (1987). Clinical trial of combination with pindolol, q.v., in essential hypertension: D. Crowder, E. G. M. Cameron, Curr. Med. Res. Opin. 6, 342 (1979).

Derivative Type: Mixture with pindolol
CAS Registry Number: 71789-16-7
Trademarks: Viskaldix (Novartis)

Derivative Type: Hydrazine deriv
Properties: Crystals from methanol + diisopropyl ether, mp 244-246°.
Melting point: mp 244-246°

Therap-Cat: Antihypertensive; diuretic.
Keywords: Antihypertensive; Sulfonamide Derivatives; Diuretic; Sulfonamide Derivatives.