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CAS No 65141-46-0 , 2-(pyridine-3-carbonylamino)ethyl nitrate

  • Name: 2-(pyridine-3-carbonylamino)ethyl nitrate
  • Synonyms: Nicorandilum; 65141-46-0; Ikorel; Sigmart; 2-Nicotinamidoethyl nitrate;Dancor; SG-75; Adancor;2-(pyridine-3-carbonylamino)ethyl nitrate; Nikoran;
  • CAS Registry Number:
  • Melting Point: 92 ºC
  • Density: 1.331 g/cm3
  • Refractive index: 1.547
  • EINECS: 265-514-1
  • Molecular Weight: 211.17476
  • InchiKey: LBHIOVVIQHSOQN-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,
    (H,10,12)
  • Molecular Formula: C8H9N3O4
  • Molecular Structure:CAS No:65141-46-0 2-(pyridine-3-carbonylamino)ethyl nitrate

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References of 2-(pyridine-3-carbonylamino)ethyl nitrate
Title: Nicorandil
CAS Registry Number: 65141-46-0
CAS Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
Synonyms: N-(2-hydroxyethyl)nicotinamide nitrate (ester)
Manufacturers' Codes: SG-75
Trademarks: Adancor (Merck-Cl¢enot); Ikorel (RPR); Perisalol (Chugai); Sigmart (Chugai)
Molecular Formula: C8H9N3O4
Molecular Weight: 211.17
Percent Composition: C 45.50%, H 4.30%, N 19.90%, O 30.31%
Literature References: Nicotinamide derivative; exhibits dual mechanism of action as both nitrovasodilator and potassium channel activator. Prepn: H. Nagano et al., DE 2714713; eidem, US 4200640 (1977, 1980 both to Chugai). Pharmacology: N. Taira et al., Clin. Exp. Pharmacol. Physiol. 6, 301 (1979). Mechanism of action: F. Yoneyama et al., Cardiovasc. Drugs Ther. 4, 1119 (1990). Symposia on pharmacology and clinical efficacy: Am. J. Cardiol. 63, Suppl, 1J-85J (1989); J. Cardiovasc. Pharmacol. 20, Suppl. 3, S1-S108 (1992). Review of clinical potential in ischemic heart disease: H. Purcell, K. Fox, Br. J. Clin. Pract. 47, 150-154 (1993). Clinical prevention of coronary events in patients with angina: IONA Study Group, Lancet 359, 1269 (2002).
Properties: Colorless needles from ether/ethanol, mp 92-93°. LD50 in rats (mg/kg): 1200-1300 orally; 800-1000 i.v. (Nagano).
Melting point: mp 92-93°
Toxicity data: LD50 in rats (mg/kg): 1200-1300 orally; 800-1000 i.v. (Nagano)
Therap-Cat: Antianginal.
Keywords: Antianginal; Potassium Channel Activator/Opener.