Home > Name List By k > ketoconazole

CAS No 65277-42-1 , ketoconazole

  • Name: ketoconazole
  • Synonyms: ketoconazole;cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1h-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine;
  • CAS Registry Number:
  • Transport: UN 2811
  • Density: 139.11 cm3
  • Refractive index: -10.5 ° (C=0.4, CHCl3)
  • Safety Statements: R25,
  • Hazard Symbols: T:Toxic;
  • EINECS: 265-667-4
  • Molecular Weight: 531.44
  • InChI: InChI=1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
  • Risk Statements: S36,S45,
  • Molecular Formula: C26H28Cl2N4O4
  • Molecular Structure:CAS No:65277-42-1 ketoconazole

Related products

Search by region :

Select to

65277-42-1 KETOCONAZOLE

Contact Supplier

65277-42-1 ketoconazole

  • China SOGA ENTERPRISES ASIA GROUP [Manufacturers]
  • Tel: +86-633-8332928
  • Fax: +86-633-8352255
  • Address: No.1,Huanghai Yilu.Rizhao,Shandong null,ShandongChina
Contact Supplier

65277-42-1 ketoconazole

Contact Supplier

65277-42-1 KETOCONAZOLE

  • China Enze Chemicals Co.,Ltd [Manufacturer]
  • Tel: +(86)-(571)-8865-5925/ +86-013750849205 (mobile)
  • Fax: +(86)-(571)5627-7156
  • Address: Industry develop area Meicheng Town,
    Jiande, H/Z, China null,nullChina
Contact Supplier

65277-42-1 ketoconazole

  • China Shanghai CelChem Company [Manufacturers]
  • Tel: +86-(21)-64573501, 64573502
  • Fax: +86-(21)-64573822
  • Address: Room 210, Zhonghuang Building, No. 1007, 2nd South Zongshan Road, Shanghai 200030, shanghai,ShanghaiChina
Contact Supplier

65277-42-1 Ketoconazole

  • India Ions Pharma null
  • Tel: +91-(22)-25006213
  • Fax: +91-(22)-66756811
  • Address: A-106/107. Kanara Business Centre (KBC), Near Laxmi Nagar. Ghatkopar (E), Mumbai, Maharashtra 400086, null,nullIndia
Contact Supplier

65277-42-1 ketoconazole

  • China BSM Chemical Co.,Ltd. null
  • Fax: 86-575-82738300 86-574-87265045
  • Address: Hangzhou Gulf Fine Chemical Zone , Shangyu , Zhejiang ,China null,nullChina
Contact Supplier

65277-42-1 Ketoconazole USP

  • China Shandong Haodesen Chemical Co., Ltd. [Manufacturers]
  • Tel: +86-(533)-3811389
  • Fax: +86-(533)-3810312
  • Address: No.15 St building, Yuqiao Garden Subdistrict, High-New Technology Zone, Zibo, Shandong 255000, Zibo,ShandongChina
Contact Supplier

65277-42-1 KETOCONAZOLE

  • United States American International Chemical, Inc. [Manufacturer]
  • Tel: 800-238-0001
  • Fax: 508-872-1566
  • Address: American International Chemical, Inc.
    135 Newbury St.
    Framingham, MA 01701 null,nullUnited States
Contact Supplier

65277-42-1 Ketoconazole USP

  • China M.C.Biotec Inc. [Manufacturers]
  • Tel: +86-(25)-86620042
  • Fax: +86-(10)-80115555 ext 441505
  • Address: No.40 Ma Jia Street, Nanjing, Jiangsu 210009, Nanjing,Jiang suChina
Contact Supplier

Select to

11/15
Previous 6 7 8 9 10 11 12 13 14 15 Next
References of ketoconazole
Title: Ketoconazole
CAS Registry Number: 65277-42-1
CAS Name: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
Manufacturers' Codes: R-41400
Trademarks: Fungarest (Janssen); Fungoral (Janssen); Ketoderm (Janssen); Ketoisdin (Isdin); Nizoral (Janssen); Orifungal M (Janssen); Panfungol (Esteve)
Molecular Formula: C26H28Cl2N4O4
Molecular Weight: 531.43
Percent Composition: C 58.76%, H 5.31%, Cl 13.34%, N 10.54%, O 12.04%
Literature References: Orally active, broad-spectrum antimycotic. Prepn: J. Heeres et al., DE 2804096, eidem, US 4144346 and US 4223036 (1978, 1979, 1980, all to Janssen); eidem, J. Med. Chem. 22, 1003 (1979). Pharmacokinetics: E. W. Gascoigne et al., Clin. Res. Rev. 1, 177 (1981); C. Brass et al., Antimicrob. Agents Chemother. 21, 151 (1982). HPLC determn in human serum: V. L. Pascucci et al., J. Pharm. Sci. 72, 1467 (1983). Series of articles on animal and human studies: Rev. Infect. Dis. 2, 519-692 (1980). Effect on hepatic enzymes in vitro and in vivo: K. N. Buchi et al., Biochem. Pharmacol. 35, 2845 (1986); J. K. Ritter, M. R. Franklin, Toxicol. Lett. 36, 51 (1987). Case reports of hepatic toxicity: J. K. Heiberg, E. Svejgaard, Br. Med. J. 283, 825 (1981); R. Rollman, L. Loof, Br. J. Dermatol. 108, 376 (1983). Controlled clinical trials: E. A. Petersen et al., Ann. Intern. Med. 93, 791 (1980); W. T. Hughes et al., J. Infect. Dis. 147, 1060 (1983); H. W. Jolly et al., Cutis 31, 208 (1983). Clinical evaluation as inhibitor of steroid synthesis: N. Sonino, N. Engl. J. Med. 317, 812 (1987). Review of pharmacology and therapeutic efficacy: C. A. Sohn, Clin. Pharm. 1, 217 (1982); R. C. Heel et al., Drugs 23, 1-36 (1982). Series of articles on clinical efficacy and therapeutic experience: Drugs Exp. Clin. Res. 12, 397-427 (1986).
Properties: Crystals from 4-methyl-2-pentanone, mp 146°. LD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel).
Melting point: mp 146°
Toxicity data: LD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel)
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Imidazoles.