Home > Name List By 1 > 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan- 2-ol Germany

CAS No 66722-44-9 , 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-
2-ol Search by region : Germany

  • Name: 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-
    2-ol
  • Synonyms: Isoten; Detensiel; Cardicor; Euradal;Concor;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-
    2-ol; Soloc; Emconcor; Bisoprololum; Zebeta;
  • CAS Registry Number:
  • Density: 1.033 g/cm3
  • Molecular Weight: 325.44304
  • InchiKey: VHYCDWMUTMEGQY-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-
    10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3
  • Molecular Formula: C18H31NO4
  • Molecular Structure:CAS No:66722-44-9 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-<br />2-ol

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66722-44-9 Bisoprolol fumerate

  • Bisoprolol fumerate
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
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References of 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-
2-ol
Title: Bisoprolol
CAS Registry Number: 66722-44-9
CAS Name: 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol
Synonyms: (±)-1-[[a-(2-isopropoxyethoxy)-p-tolyl]oxy]-3-(isopropylamino)-2-propanol; (±)-1-[p-(2-isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)-2-propanol
Manufacturers' Codes: EMD-33512
Molecular Formula: C18H31NO4
Molecular Weight: 325.44
Percent Composition: C 66.43%, H 9.60%, N 4.30%, O 19.66%
Literature References: Cardioselective b1-adrenergic blocker. Prepn: BE 859425; R. Jonas et al., US 4258062 (1978, 1981 both to E. Merck). Clinical pharmacology: A. E. Tattersfield et al., Br. J. Clin. Pharmacol. 18, 343 (1984); P. Dorow, U. T?nnesmann, Eur. J. Clin. Pharmacol. 27, 135 (1984). Binding study of (-)-form: A. J. Kaumann, H. Lemoine, Arch. Pharmacol. 331, 27 (1985). HPLC determn of enantiomers in plasma and urine: T. Suzuki et al., J. Chromatogr. 619, 267 (1993). Clinical evaluation in angina: R. S. Kohli et al., Eur. Heart J. 6, 845 (1985); in hypertension: F. R. Bühler et al., J. Cardiovasc. Pharmacol. 8, Suppl. 11, S122 (1986). Review of pharmacokinetics: J. Grevel et al., Clin. Pharmacokinet. 17, 53-63 (1989); of clinical efficacy in combination with hydrochlorothiazide: P. K. Zachariah et al., Clin. Ther. 15, 779-787 (1993). Clinical trial in chronic heart failure: CIBIS-II Investigators, Lancet 353, 9 (1999).
 
Derivative Type: Hemifumarate
CAS Registry Number: 104344-23-2
Trademarks: Concor (Merck KGaA); Detensiel (Merck-Cl¢enot); Emconcor (Merck KGaA); Emcor (Merck KGaA); Euradal (Lacer); Isoten (Lederle); Monocor (Am. Cyanamid); Soprol (Lederle); Zebeta (Lederle)
Molecular Formula: C18H31NO4.?C4H4O4
Molecular Weight: 383.48
Percent Composition: C 62.64%, H 8.67%, N 3.65%, O 25.03%
Properties: Crystals, mp 100°. Sol in ethanol.
Melting point: mp 100°
 
Derivative Type: Mixture with hydrochlorothiazide
Trademarks: Ziac (Am. Cyanamid)
 
Therap-Cat: Antihypertensive.
Keywords: ?Adrenergic Blocker; Antihypertensive; Aryloxypropanolamine Derivatives.