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CAS No 671-16-9 , 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide Search by region : India

  • Name: 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide
  • Synonyms: Ibenzmethyzine; Natulanar; Procarbazin; Ibenzmethyzin;4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide; Procarbazina; Procarbazin [German]; Procarbazinum;Natulan;
  • CAS Registry Number:
  • Density: 1.035 g/cm3
  • Safety Statements: Questional carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intravenous route. Moderately toxic by intraperitoneal route. Has been implicated as a brain carcinogen. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 211-582-2
  • Molecular Weight: 221.29876
  • InchiKey: CPTBDICYNRMXFX-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,
    13-14H,8H2,1-3H3,(H,15,16)
  • Molecular Formula: C12H19N3O
  • Molecular Structure:CAS No:671-16-9 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide

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671-16-9 Procarbazine

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References of 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide
Title: Procarbazine
CAS Registry Number: 671-16-9
CAS Name: N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
Synonyms: N-isopropyl-a-(2-methylhydrazino)-p-toluamide; N-4-isopropylcarbamoylbenzyl-N￠-methylhydrazine; p-(N1-methylhydrazinomethyl)-N-isopropylbenzamide; ibenzmethyzin; MIH
Manufacturers' Codes: Ro-4-6467
Molecular Formula: C12H19N3O
Molecular Weight: 221.30
Percent Composition: C 65.13%, H 8.65%, N 18.99%, O 7.23%
Literature References: Alkylating agent. Prepn: BE 618638; W. Bollag et al., US 3520926 (1962, 1970 to Hoffmann-La Roche). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: R. J. Rucki, Anal. Profiles Drug Subs. 5, 403-427 (1976). HPLC determn in plasma: X. He et al., J. Chromatogr. B 799, 281 (2004). Review of clinical experience in hematological malignancies: M. Massoud et al., Eur. J. Cancer 40, 1924-1927 (2004).
 
Derivative Type: Hydrochloride
CAS Registry Number: 366-70-1
Trademarks: Matulane (Roche); Natulan (Roche)
Molecular Formula: C12H19N3O.HCl
Molecular Weight: 257.76
Percent Composition: C 55.92%, H 7.82%, N 16.30%, O 6.21%, Cl 13.75%
Properties: Crystals from methanol, mp 223-226°. LD50 orally in rats: 785 ±34 mg/kg (Goldenthal).
Melting point: mp 223-226°
Toxicity data: LD50 orally in rats: 785 ±34 mg/kg (Goldenthal)
 
Derivative Type: Hydrobromide
Molecular Formula: C12H19N3O.HBr
Molecular Weight: 302.21
Percent Composition: C 47.69%, H 6.67%, N 13.90%, O 5.29%, Br 26.44%
Properties: Crystals from methanol + ether, dec 216-217°.
 
CAUTION: Procarbazine hydrochloride is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-222.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents.