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CAS No 67392-87-4 , Drospirenone

  • Name: Drospirenone
  • Synonyms: 1,2-Dihydrospirorenone; Dehydrospirorenone;Dihydrospirorenone; Drospirenonum [INN-Latin]; Drospirenona;Drospirenone; Drospirenonum; DRSP;
  • CAS Registry Number:
  • Melting Point: 196-200 ºC
  • Flash Point: 241.6 ºC
  • Boiling Point: 552.2 ºC at 760 mmHg
  • Density: 1.26 g/cm3
  • Refractive index: 1.61
  • Alpha: -180 º (C=0.5, CHLOROFORM)
  • Flash Point: 241.6 ºC
  • EINECS: 266-679-2
  • Molecular Weight: 366.4932
  • InchiKey: METQSPRSQINEEU-HXCATZOESA-N
  • InChI: InChI=1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)
    21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,
    1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
  • Molecular Formula: C24H30O3
  • Molecular Structure:CAS No:67392-87-4 Drospirenone

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References of Drospirenone
Title: Drospirenone
CAS Registry Number: 67392-87-4
CAS Name: (2￠S,6R,7R,8R,9S,10R,13S,14S,15S,16S)-1,3￠,4￠,6,7,8,9,10,11,12,13,14,15,16,20,21-Hexadecahydro-10,13-dimethylspiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2￠(5￠H)-furan]-3,5￠(2H)-dione
Synonyms: 6b,7b,15b,16b-dimethylene-3-oxo-4-androstene-[17(b-1￠)-spiro-5￠]perhydrofuran-2￠-one; 6b,7b,15b,16b-dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone; dihydrospirorenone
Manufacturers' Codes: ZK-30595
Molecular Formula: C24H30O3
Molecular Weight: 366.49
Percent Composition: C 78.65%, H 8.25%, O 13.10%
Literature References: Synthetic progestogen exhibiting antimineralocorticoid and antiandrogenic activity. Prepn: R. Wiechert et al., DE 2652761; eidem, US 4129564 (both 1978 to Schering AG); D. Bittler et al., Angew. Chem. 94, 718 (1982). HPLC determn in human plasma: W. Krause, U. Jakobs, J. Chromatogr. 230, 37 (1982). Pharmacological profile: P. Muhn et al., Contraception 51, 99 (1995). Review of synthesis: H. Laurent et al., J. Steroid Biochem. 19, 771-776 (1983); of pharmacology and clinical experience: W. Oelkers, Mol. Cell. Endocrinol. 217, 255-261 (2004).
Properties: mp 201.3°. [a]D22 -182° (c = 0.5 in chloroform). uv (methanol): 265 nm (e 19000).
Melting point: mp 201.3°
Optical Rotation: [a]D22 -182° (c = 0.5 in chloroform)
 
Derivative Type: Mixture with ethinyl estradiol
Trademarks: Angeliq (Schering AG); Yasmin (Schering AG)
Literature References: Clinical trial as oral contraceptive: K. S. Parsey, A. Pong, Contraception 61, 105 (2000); in treatment of menopausal symptoms: R. Schürmann et al., Climacteric 7, 189 (2004).
 
Therap-Cat: Progestogen. In combination with estrogen as oral contaceptive and in treatment of menopausal symptoms.
Keywords: Progestogen; Contraceptive (Oral).