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CAS No 68302-57-8 , 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid

  • Name: 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid
  • Synonyms: Amlexanoxo [Spanish]; Amoxanox; Solfa; Amlenanox;2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid;Aphthasol; 68302-57-8; Elics; Amlexanoxum [Latin]; Amlexanoxum;
  • CAS Registry Number:
  • Melting Point: >3000 ºC
  • Flash Point: 298.5 ºC
  • Boiling Point: 570 ºC at 760 mmHg
  • Density: 1.408 g/cm3
  • Refractive index: 1.668
  • Flash Point: 298.5 ºC
  • Molecular Weight: 298.29336
  • InchiKey: SGRYPYWGNKJSDL-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)
    18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
  • Molecular Formula: C16H14N2O4
  • Molecular Structure:CAS No:68302-57-8 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid

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References of 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid
Title: Amlexanox
CAS Registry Number: 68302-57-8
CAS Name: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Synonyms: 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid; 2-amino-7-isopropyl-1-azaxanthone-3-carboxylic acid; amoxanox
Manufacturers' Codes: AA-673; CHX-3673
Trademarks: Aphthasol (Block); Elics (Senju); Solfa (Takeda)
Molecular Formula: C16H14N2O4
Molecular Weight: 298.29
Percent Composition: C 64.42%, H 4.73%, N 9.39%, O 21.45%
Literature References: Inhibits release of allergic mediators from mast cells. Prepn: A. Nohara et al., BE 864647; US 4143042 (1978, 1979 both to Takeda); eidem, J. Med. Chem. 28, 559 (1985). Mode of action studies: T. Saijo et al., Int. Arch. Allergy Appl. Immunol. 79, 231 (1986); H. Makino et al., ibid. 82, 66 (1987). Pharmacodynamics: G. Rankov et al., Ophthalmic Res. 22, 359 (1990). Clinical trial in aphthous ulcers: R. O. Greer, Jr. et al., J. Oral Maxillofac. Surg. 51, 243 (1993).
Properties: Crystals from DMF, mp >300°.
Melting point: mp >300°
Therap-Cat: Antiallergic; antiasthmatic.
Keywords: Antiallergic; Antiasthmatic (Nonbronchodilator); 5-Lipoxygenase Inhibitor.