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CAS No 69-25-0 , Eledoisin

  • Name: Eledoisin
  • Synonyms: Eledoisin;5-Oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide;
  • CAS Registry Number:
  • Density: 1.289 g/cm3
  • Refractive index: 1.569
  • Molecular Weight: 1188.40
  • InChI: InChI=1/C54H85N13O15S/c1-7-30(4)44(53(81)57-27-42(70)60-36(24-29(2)3)49(77)61-33(45(56)73)20-23-83-6)66-50(78)37(25-32-14-9-8-10-15-32)63-46(74)31(5)58-48(76)38(26-43(71)72)64-47(75)34(16-11-12-21-55)62-51(79)39(28-68)65-52(80)40-17-13-22-67(40)54(82)35-18-19-41(69)59-35/h8-10,14-15,29-31,33-40,44,68H,7,11-13,16-28,55H2,1-6H3,(H2,56,73)(H,57,81)(H,58,76)(H,59,69)(H,60,70)(H,61,77)(H,62,79)(H,63,74)(H,64,75)(H,65,80)(H,66,78)(H,71,72)/t30-,31-,33-,34-,35-,36-,37-,38-,39-,40-,44-/m0/s1
  • Molecular Formula: C54H85N13O15S
  • Molecular Structure:CAS No:69-25-0 Eledoisin

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  • Eledoisin Acetate Sequence: pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2 Cas No.: 69-25-0 Molecular Formula: C54H85N13O15S Molecular Weight: 1188.44 Purity (HPLC): 99.0% Appearance: White powder Single Impurity (HPLC): 0.5% Amino Acid Composition...
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69-25-0 Eledoisin

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69-25-0 Eledoisin

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69-25-0 Eledoisin

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References of Eledoisin
Title: Eledoisin
CAS Registry Number: 69-25-0
Molecular Formula: C54H85N13O15S
Molecular Weight: 1188.40
Percent Composition: C 54.58%, H 7.21%, N 15.32%, O 20.19%, S 2.70%
Literature References: A hendecapeptide from the posterior salivary glands of eledone spp (small octopus spp): Anastasi, Erspamer, Br. J. Pharmacol. 19, 326 (1962); eidem, Experientia 18, 58 (1962). Synthesis: Sandrin, Boissonnas, ibid. 59; eidem, Helv. Chim. Acta 47, 1294 (1964); Lubke et al., Ann. 679, 195 (1964); GB 984810 (1965 to Farmitalia); solid-phase synthesis: P. G. Pietta et al., J. Org. Chem. 39, 44 (1974). Its physiologic action resembles that of the other tachykinins, substance P and physalaemin, q.q.v. Stimulates extravascular smooth muscle, acts as a potent vasodilator and hypotensive agent; in certain species causes salivation, and increases capillary permeability. Pharmacology: Erspamer, Erspamer, Br. J. Pharmacol. 19, 337 (1962); Sicuteri et al., Experientia 19, 44 (1963); G. Bertaccini, Pharmacol. Rev. 28, 127 (1976). Review: Erd?s, Adv. Pharmacol. 4, 64-72 (1966).
 
Derivative Type: Sesquihydrate
Properties: Powder, dec 230°. [a]D22 -44° (c = 1 in 95% acetic acid). Slowly loses activity when incubated in blood.
Optical Rotation: [a]D22 -44° (c = 1 in 95% acetic acid)
 
Derivative Type: Trifluoroacetate
CAS Registry Number: 10129-92-7
Trademarks: Eloisin (Farmitalia)
Molecular Formula: C54H85N13O15S.C2HF3O2
Molecular Weight: 1302.42
Percent Composition: C 51.64%, H 6.66%, N 13.98%, O 20.88%, S 2.46%, F 4.38%
 
Therap-Cat: Hypotensive; stimulator of lacrimal secretion.
Keywords: Vasodilator (Peripheral).