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CAS No 70356-03-5 , Cefaclor monohydrate Search by region : Canada

  • Name: Cefaclor monohydrate
  • Synonyms: cefaclor; Cefactor;Cefaclor monohydrate;3-chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid monohydrate;8-(2-Amino-2-phenylacetyl)amino-4-chloro-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid monohydrate; Ceclor;
  • CAS Registry Number:
  • Safety Statements: Moderately toxic by intraperitoneal route. Mildly toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx.
  • EINECS: 258-909-5
  • Molecular Weight: 385.82
  • InChI: InChI=1/C15H14ClN3O4S.H2O/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7;/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23);1H2/t9-,10-,14-;/m1./s1
  • Molecular Formula: C15H14ClN3O4S.H2O
  • Molecular Structure:CAS No:70356-03-5 Cefaclor monohydrate

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70356-03-5 CEFACLOR

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References of Cefaclor monohydrate
Title: Cefaclor
CAS Registry Number: 70356-03-5
CAS Name: (6R,7R)-7-[[(2R)-Aminophenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate
Synonyms: 7-(D-2-amino-2-phenylacetamido)-3-chloro-3-cephem-4-carboxylic acid monohydrate; 3-chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid monohydrate
Manufacturers' Codes: compd 99638
Trademarks: Alfacet (Galenika); Alfatil (Lilly); Ceclor (Lilly); Distaclor (Lilly); Panacef (Lilly); Panoral (Lilly)
Molecular Formula: C15H14ClN3O4S.H2O
Molecular Weight: 385.82
Percent Composition: C 46.70%, H 4.18%, Cl 9.19%, N 10.89%, O 20.73%, S 8.31%
Literature References: Semi-synthetic cephalosporin antibiotic, related to cephalexin, q.v. Prepn: R. R. Chauvette, DE 2408698 (1974 to Lilly), C.A. 82, 4278n (1975); US 3925372 (1975 to Lilly); R. R. Chauvette, P. A. Pennington, J. Med. Chem. 18, 403 (1975). In vitro studies: M. S. Silver et al., Antimicrob. Agents Chemother. 12, 591 (1977); R. N. Jones, J. Antibiot. 30, 753 (1977); B. R. Meyers, S. Z. Hirschman, J. Clin. Pharmacol. 18, 85 (1978). Metabolism: N. G. Waterman, L. F. Sharfenberger, Antimicrob. Agents Chemother. 14, 614 (1978). Human pharmacology: G. R. Hodges et al., ibid. 454; A. Glynne et al., J. Antimicrob. Chemother. 4, 343 (1978). Clinical studies: J. D. Nelson et al., Am. J. Dis. Child. 132, 992 (1978); B. M. Gray et al., Antimicrob. Agents Chemother. 13, 988 (1978). Comprehensive description: L. J. Lorenz, Anal. Profiles Drug Subs. 9, 107-123 (1980).
Properties: Crystalline solid. uv max (pH 7 buffer): 265 nm (e 6800). Sol in water. Practically insol in methanol, chloroform, benzene. Solns are stable at pH 2.5-4.5.
Absorption maximum: uv max (pH 7 buffer): 265 nm (e 6800)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.