Home > Name List By 6 > 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2, 3-e]thiazine-3-carboxamide

CAS No 70374-39-9 , 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,
3-e]thiazine-3-carboxamide

  • Name: 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,
    3-e]thiazine-3-carboxamide
  • Synonyms: 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,
    3-e]thiazine-3-carboxamide; Taigalor;Chlortenoxicam; Safem; Xefo; Lornoxicamum; 70374-39-9; Lorcam; Acabel; Xefocam;
  • CAS Registry Number:
  • Density: 1.727g/cm3
  • Refractive index: 1.741
  • Safety Statements: 26-36
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 371.8192
  • InchiKey: WLHQHAUOOXYABV-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23
    (17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
  • Risk Statements: 36/37/38
  • Molecular Formula: C13H10ClN3O4S2
  • Molecular Structure:CAS No:70374-39-9 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,<br />3-e]thiazine-3-carboxamide

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References of 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,
3-e]thiazine-3-carboxamide
Title: Lornoxicam
CAS Registry Number: 70374-39-9
CAS Name: 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide
Synonyms: 6-chloro-4-hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-2H-thieno[2,3-e]-1,2-thiazine-1,1-dioxide; chlortenoxicam
Manufacturers' Codes: Ro-13-9297; TS-110
Trademarks: Xefo (Nycomed)
Molecular Formula: C13H10ClN3O4S2
Molecular Weight: 371.82
Percent Composition: C 41.99%, H 2.71%, Cl 9.53%, N 11.30%, O 17.21%, S 17.25%
Literature References: Cyclooxygenase inhibitor; structurally similar to tenoxicam, q.v. Prepn: R. Pfister et al., DE 2838851; eidem, US 4180662 (both 1979 to Hoffmann-La Roche). Clinical pharmacokinetics: S. I. Ankier et al., Postgrad. Med. J. 64, 752 (1988). Symposium on pharmacology and clinical experience: ibid. 66, Suppl. 4, S1-S50 (1990). Overview of pharmacology and safety assessment: T. P. Pruss et al., ibid. S18.
Properties: Orange to yellow crystals, mp 225-230° (dec). pKa2 4.7. uv max: 371 nm. Partition coefficient (n-octanol/pH 7.4 buffer): 1.8. LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss).
Melting point: mp 225-230° (dec)
pKa: pKa2 4.7
Log P: Partition coefficient (n-octanol/pH 7.4 buffer): 1.8
Absorption maximum: uv max: 371 nm
Toxicity data: LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Thiazinecarboxamides.