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CAS No 72432-03-2 , (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

  • Name: (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
  • Synonyms: Glyset; Seibule; Glyset (TN); Diastabol; Bay-m-1099; 72432-03-2; Plumarol;(2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol; CHEMBL1561; AC1L9AYD;
  • CAS Registry Number:
  • Melting Point: 114 ºC
  • Density: 1.458 g/cm3
  • Refractive index: 1.597
  • EINECS: 276-661-6
  • Molecular Weight: 207.22428
  • InchiKey: IBAQFPQHRJAVAV-ULAWRXDQSA-N
  • InChI: InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,
    1-4H2/t5-,6+,7-,8-/m1/s1
  • Molecular Formula: C8H17NO5
  • Molecular Structure:CAS No:72432-03-2 (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

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72432-03-2 A1879 N-(B-HYDROXYETHYL)-1-DEOXYNOJIRIMYCIN

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References of (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
Title: Miglitol
CAS Registry Number: 72432-03-2
CAS Name: 1,5-Dideoxy-1,5-[(2-hydroxyethyl)imino]-D-glucitol
Synonyms: N-(2-hydroxyethyl)moranoline; (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol; N-(b-hydroxyethyl)-1-deoxynojirimycin
Manufacturers' Codes: Bay m 1099
Trademarks: Diastabol (Sanofi-Synthelabo); Glyset (Pfizer)
Molecular Formula: C8H17NO5
Molecular Weight: 207.22
Percent Composition: C 46.37%, H 8.27%, N 6.76%, O 38.60%
Literature References: a-Glucosidase inhibitor; hydroxyethyl derivative of 1-deoxynojirimycin, q.v. Prepn: B. Junge et al., DE 2758025; eidem, US 4639436 (1979, 1987 both to Bayer AG). Inhibition of a-glucosidase: B. Lembcke et al., Digestion 31, 120 (1985); and hypoglycemic activity: Y. Yoshikuni et al., J. Pharmacobio-Dyn. 11, 356 (1988). Clinical evaluations in insulin dependent diabetes: J. Gerard et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 25, 483 (1987); F. P. Kennedy, J. E. Gerich, Clin. Pharmacol. Ther. 42, 455 (1987). Review of pharmacology, clinical efficacy, and therapeutic potential in non-insulin dependent diabetes: L. J. Scott, C. M. Spencer, Drugs 59, 521-549 (2000).
Properties: Crystals from ethanol, mp 114°. Sol in water. pKa 5.9.
Melting point: mp 114°
pKa: pKa 5.9
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; a-Glucosidase Inhibitor.