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CAS No 72558-82-8 , Ceftazidime

  • Name: Ceftazidime
  • Synonyms: 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl]methyl]pyridinum hydroxide inner salt;Ceftazidime; 1-(((6r,7r)-7-(((2z)-(2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino) acetyl) amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0) oct-2-en-3-yl)methyl)pyridinum hydroxide inner salt;Ceftazidime anhydrous;
  • CAS Registry Number:
  • Transport: colorless crystal or white powder
  • Safety Statements: 26-36
  • Hazard Symbols: Xn
  • EINECS: 276-715-9
  • Molecular Weight: 546.58
  • InChI: InChI=1/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1
  • Risk Statements: 20/21/22-36/37/38
  • Molecular Formula: C22H22N6O7S2
  • Molecular Structure:CAS No:72558-82-8 Ceftazidime

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References of Ceftazidime
Title: Ceftazidime
CAS Registry Number: 72558-82-8
CAS Name: 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium inner salt
Synonyms: 1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium hydroxide inner salt 72-(Z)-[O-(1-carboxy-1-methylethyl)oxime]
Manufacturers' Codes: GR-20263
Molecular Formula: C22H22N6O7S2
Molecular Weight: 546.58
Percent Composition: C 48.34%, H 4.06%, N 15.38%, O 20.49%, S 11.73%
Literature References: Third generation cephalosporin antibiotic. Prepn: C. H. O'Callaghan et al., DE 2921316; eidem, US 4258041 (1979, 1981 both to Glaxo). Prepn of crystalline pentahydrate: A. Brodie, L. A. Wetherill, DE 3037102; eidem, US 4329453 (1981, 1982 both to Glaxo). Chemical and antibacterial properties: eidem, Antimicrob. Agents Chemother. 17, 876 (1980). Activity vs Pseudomonas and Enterobacteriaceae: L. Verbist, J. Verhaegen, ibid. 807. In vitro comparison with other b-lactams: R. Wise et al., ibid. 884; L. Verbist, ibid. 19, 407 (1981). Symposium on clinical studies: J. Antimicrob. Chemother. 12, Suppl. A, 1-414 (1983). Review of antibacterial activity, pharmacokinetics and therapeutic use: D. M. Richards, R. N. Brogden, Drugs 29, 105-161 (1985). Comprehensive description: M. A. Abounassif et al., Anal. Profiles Drug Subs. 19, 95-121 (1990).
 
Derivative Type: Pentahydrate
CAS Registry Number: 78439-06-2
Trademarks: Fortam (GSK); Fortaz (GSK); Fortum (GSK); Fortumset (GSK); Glazidim (GSK); Kefadim (Lilly); Kefamin (Lilly); Kefazim (Lilly); Modacin (GSK); Panzid (Duncan); Spectrum (Sigma-Tau); Starcef (Firma); Tazicef (GSK); Tazidime (Lilly)
Molecular Formula: C22H22N6O7S2.5H2O
Molecular Weight: 636.65
Percent Composition: C 41.50%, H 5.07%, N 13.20%, O 30.16%, S 10.07%
Properties: Crystalline solid. uv max (pH 6): 257 nm (E1%1cm 348).
Absorption maximum: uv max (pH 6): 257 nm (E1%1cm 348)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.