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CAS No 72559-06-9 , Rifabutin Search by region : India

  • Name: Rifabutin
  • Synonyms: Rifabutine [French]; Alfacid; Mycobutin; Rifabutine;Ansamycin;Rifabutin; Antibiotic LM 427; Ansatipin; Ansatipine;
  • CAS Registry Number:
  • Transport: OTH
  • Flash Point: 540.188°C
  • Boiling Point: 969.589°C at 760 mmHg
  • Density: 1.339g/cm3
  • Refractive index: 1.623
  • Water Solubility: slightly soluble (soluble in chloroform and alcohol)
  • Hazard Symbols: UN NO.
  • Flash Point: 540.188°C
  • Molecular Weight: 847.00468
  • InchiKey: ATEBXHFBFRCZMA-VXTBVIBXSA-N
  • InChI: InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)
    28(8)42-33(31)43(56)45(10,
    61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)
    13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,
    37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,
    24-14-/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1
  • Molecular Formula: C46H62N4O11
  • Molecular Structure:CAS No:72559-06-9 Rifabutin

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References of Rifabutin
Title: Rifabutin
CAS Registry Number: 72559-06-9
CAS Name: 1￠,4-Didehydro-1-deoxy-1,4-dihydro-5￠-(2-methylpropyl)-1-oxorifamycin XIV
Synonyms: (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6,16,18,20-tetrahydroxy-1￠-isobutyl-14-methoxy-7,9,15,17,19,21,25-heptamethylspiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2￠,3￠:7,8]naphth[1,2-d]imidazole-2,4￠-piperidine]-5,10,26-(3H,9H)-trione-16-acetate; 4-deoxo-3,4-[2-spiro-(N-isobutyl-4-piperidyl)]-(1H)-imidazo-(2,5-dihydro)rifamycin S; 4-N-isobutylspiropiperidylrifamycin S
Manufacturers' Codes: LM-427
Trademarks: Ansatipine (Farmitalia); Mycobutin (Farmitalia)
Molecular Formula: C46H62N4O11
Molecular Weight: 847.00
Percent Composition: C 65.23%, H 7.38%, N 6.61%, O 20.78%
Literature References: Semisynthetic derivative of rifamycin S that inhibits nucleic acid synthesis. Prepn: L. Marsili et al., DE 2825445 (1979 to Farmitalia); eidem, US 4219478 (1980 to Archifar Labs). In vitro and in vivo antibacterial activity: A. Sanfilippo et al., J. Antibiot. 33, 1193 (1980); C. Della Bruna et al., ibid. 36, 1502 (1983). Mechanism of action: D. Ungheri et al., Drugs Exp. Clin. Res. 10, 681 (1984). Comparative in vitro antimycobacterial spectrum: J. M. Dickinson, D. A. Mitchison, Tubercle 68, 177 (1987). In vitro inhibition of HIV-1 replication: R. Anand et al., Antimicrob. Agents Chemother. 32, 684 (1988). Clinical pharmacokinetics: M. H. Skinner et al., ibid. 33, 1237 (1989). Pharmacology and clinical efficacy in mycobacterial infections: R. J. O'Brien et al., Rev. Infect. Dis. 9, 519 (1987).
Properties: Violet-red crystalline powder. Highly sol in chloroform, sol in methanol, slightly sol in ethanol, minimally sol in water. uv max (methanol): 493, 315, 274, 238 nm.
Absorption maximum: uv max (methanol): 493, 315, 274, 238 nm
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Tuberculostatic).